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Vitamin D and risk of neuroimaging abnormalities

Littlejohns, TJ and Kos, K and Henley, WE and Lang, IA and Annweiler, C and Beauchet, O and Chaves, PHM and Kestenbaum, BR and Kuller, LH and Langa, KM and Lopez, OL and Llewellyn, DJ (2016) Vitamin D and risk of neuroimaging abnormalities. PLoS ONE, 11 (5).

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Abstract

© 2016 Littlejohns et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Vitamin D deficiency has been linked with an increased risk of incident all-cause dementia and Alzheimer's disease. The aim of the current study was to explore the potential mechanisms underlying these associations by determining whether low vitamin D concentrations are associated with the development of incident cerebrovascular and neurodegenerative neuroimaging abnormalities. The population consisted of 1,658 participants aged ≥65 years from the US-based Cardiovascular Health Study who were free from prevalent cardiovascular disease, stroke and dementia at baseline in 1992-93. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were determined by liquid chromatography-tandem mass spectrometry from blood samples collected at baseline. The first MRI scan was conducted between 1991-1994 and the second MRI scan was conducted between 1997-1999. Change in white matter grade, ventricular grade and presence of infarcts between MRI scan one and two were used to define neuroimaging abnormalities. During a mean follow-up of 5.0 years, serum 25(OH)D status was not significantly associated with the development of any neuroimaging abnormalities. Using logistic regression models, the multivariate adjusted odds ratios (95% confidence interval) for worsening white matter grade in participants who were severely 25(OH)D deficient (<25 nmol/L) and deficient (≥25-50 nmol/L) were 0.76 (0.35-1.66) and 1.09 (0.76-1.55) compared to participants with sufficient concentrations (≥50 nmol/L). The multivariate adjusted odds ratios for ventricular grade in participants who were severely 25(OH)D deficient and deficient were 0.49 (0.20-1.19) and 1.12 (0.79-1.59) compared to those sufficient. The multivariate adjusted odds ratios for incident infarcts in participants who were severely 25 (OH)D deficient and deficient were 1.95 (0.84-4.54) and 0.73 (0.47-1.95) compared to those sufficient. Overall, serum vitamin D concentrations could not be shown to be associated with the development of cerebrovascular or neurodegenerative neuroimaging abnormalities in Cardiovascular Health Study participants.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Littlejohns, TJ
Kos, K
Henley, WE
Lang, IA
Annweiler, C
Beauchet, O
Chaves, PHM
Kestenbaum, BR
Kuller, LHKullerL@edc.pitt.eduKULLER
Langa, KM
Lopez, OLollopez@pitt.eduOLLOPEZ
Llewellyn, DJ
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorSlominski, Andrzej T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 1 May 2016
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: PLoS ONE
Volume: 11
Number: 5
DOI or Unique Handle: 10.1371/journal.pone.0154896
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Neurology
Refereed: Yes
Date Deposited: 31 Aug 2016 18:06
Last Modified: 02 Feb 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/28256

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