Littlejohns, TJ and Kos, K and Henley, WE and Lang, IA and Annweiler, C and Beauchet, O and Chaves, PHM and Kestenbaum, BR and Kuller, LH and Langa, KM and Lopez, OL and Llewellyn, DJ
(2016)
Vitamin D and risk of neuroimaging abnormalities.
PLoS ONE, 11 (5).
Abstract
Vitamin D deficiency has been linked with an increased risk of incident all-cause dementia and Alzheimer's disease. The aim of the current study was to explore the potential mechanisms underlying these associations by determining whether low vitamin D concentrations are associated with the development of incident cerebrovascular and neurodegenerative neuroimaging abnormalities. The population consisted of 1,658 participants aged ≥65 years from the US-based Cardiovascular Health Study who were free from prevalent cardiovascular disease, stroke and dementia at baseline in 1992-93. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were determined by liquid chromatography-tandem mass spectrometry from blood samples collected at baseline. The first MRI scan was conducted between 1991-1994 and the second MRI scan was conducted between 1997-1999. Change in white matter grade, ventricular grade and presence of infarcts between MRI scan one and two were used to define neuroimaging abnormalities. During a mean follow-up of 5.0 years, serum 25(OH)D status was not significantly associated with the development of any neuroimaging abnormalities. Using logistic regression models, the multivariate adjusted odds ratios (95% confidence interval) for worsening white matter grade in participants who were severely 25(OH)D deficient (<25 nmol/L) and deficient (≥25-50 nmol/L) were 0.76 (0.35-1.66) and 1.09 (0.76-1.55) compared to participants with sufficient concentrations (≥50 nmol/L). The multivariate adjusted odds ratios for ventricular grade in participants who were severely 25(OH)D deficient and deficient were 0.49 (0.20-1.19) and 1.12 (0.79-1.59) compared to those sufficient. The multivariate adjusted odds ratios for incident infarcts in participants who were severely 25 (OH)D deficient and deficient were 1.95 (0.84-4.54) and 0.73 (0.47-1.95) compared to those sufficient. Overall, serum vitamin D concentrations could not be shown to be associated with the development of cerebrovascular or neurodegenerative neuroimaging abnormalities in Cardiovascular Health Study participants.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
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Littlejohns, TJ | | | | Kos, K | | | | Henley, WE | | | | Lang, IA | | | | Annweiler, C | | | | Beauchet, O | | | | Chaves, PHM | | | | Kestenbaum, BR | | | | Kuller, LH | kuller@pitt.edu | KULLER | | Langa, KM | | | | Lopez, OL | ollopez@pitt.edu | OLLOPEZ | | Llewellyn, DJ | | | |
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Contributors: |
Contribution | Contributors Name | Email | Pitt Username | ORCID  |
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Editor | Slominski, Andrzej T. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
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Date: |
1 May 2016 |
Date Type: |
Publication |
Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
Journal or Publication Title: |
PLoS ONE |
Volume: |
11 |
Number: |
5 |
DOI or Unique Handle: |
10.1371/journal.pone.0154896 |
Institution: |
University of Pittsburgh |
Schools and Programs: |
School of Medicine > Neurology |
Refereed: |
Yes |
Date Deposited: |
31 Aug 2016 18:06 |
Last Modified: |
02 Nov 2022 11:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/28256 |
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