Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Fronto-limbic brain dysfunction during the regulation of emotion in schizophrenia

Eack, SM and Wojtalik, JA and Barb, SM and Newhill, CE and Keshavan, MS and Phillips, ML (2016) Fronto-limbic brain dysfunction during the regulation of emotion in schizophrenia. PLoS ONE, 11 (3).

[img]
Preview
PDF
Published Version
Available under License : See the attached license file.

Download (606kB)
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

© 2016 Eack et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Schizophrenia is characterized by significant and widespread impairments in the regulation of emotion. Evidence is only recently emerging regarding the neural basis of these emotion regulation impairments, and few studies have focused on the regulation of emotion during effortful cognitive processing. To examine the neural correlates of deficits in effortful emotion regulation, schizophrenia outpatients (N = 20) and age- and gender-matched healthy volunteers (N = 20) completed an emotional faces n-back task to assess the voluntary attentional control subprocess of emotion regulation during functional magnetic resonance imaging. Behavioral measures of emotional intelligence and emotion perception were administered to examine brain-behavior relationships with emotion processing outcomes. Results indicated that patients with schizophrenia demonstrated significantly greater activation in the bilateral striatum, ventromedial prefrontal, and right orbitofrontal cortices during the effortful regulation of positive emotional stimuli, and reduced activity in these same regions when regulating negative emotional information. The opposite pattern of results was observed in healthy individuals. Greater fronto-striatal response to positive emotional distractors was significantly associated with deficits in facial emotion recognition. These findings indicate that abnormalities in striatal and prefrontal cortical systems may be related to deficits in the effortful emotion regulatory process of attentional control in schizophrenia, and may significantly contribute to emotion processing deficits in the disorder.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Eack, SMsme12@pitt.eduSME12
Wojtalik, JAjew103@pitt.eduJEW103
Barb, SMsmb86@pitt.eduSMB86
Newhill, CEnewhill@pitt.eduNEWHILL
Keshavan, MSkeshavan@pitt.eduKESHAVAN
Phillips, ML
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorPavlova, Marina A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 1 March 2016
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: PLoS ONE
Volume: 11
Number: 3
DOI or Unique Handle: 10.1371/journal.pone.0149297
Institution: University of Pittsburgh
Schools and Programs: School of Social Work > Social Work
Refereed: Yes
Date Deposited: 23 Aug 2016 15:09
Last Modified: 02 Feb 2019 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/28301

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item