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APOBEC3G variants and protection against HIV-1 infection in Burkina Faso

Compaore, TR and Soubeiga, ST and Ouattara, AK and Obiri-Yeboah, D and Tchelougou, D and Maiga, M and Assih, M and Bisseye, C and Bakouan, D and Compaore, IP and Dembele, A and Martinson, J and Simpore, J (2016) APOBEC3G variants and protection against HIV-1 infection in Burkina Faso. PLoS ONE, 11 (1).

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Abstract

© 2016 Compaore et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Studies on host factors, particularly the APOBEC3G gene, have previously found an association with AIDS progression in some populations and against some HIV-1 strains but not others. Our study had two main objectives: firstly, to screen a population from Burkina Faso for three variants of APOBEC3G previously described, and secondly to analyze the effect of these three variants and their haplotypes on HIV-1 infection with Circulating Recombinant Forms (CRFs) present in Burkina Faso. This case control study involved 708 seropositive and seronegative individuals. Genotyping was done by the TaqMan allelic discrimination method. Minor allele frequencies of rs6001417 (p<0.05), rs8177832 (P<0.05), and rs35228531 (P<0.001) were higher in seronegative subjects. The rs6001417 and rs8177832 SNPs were associated with HIV-1 infection in an additive model (P<0.01). Furthermore the SNP rs35228531 was also associated with HIV-1 infection in a dominant model (P<0.001). Odds ratio analysis of genotypes and alleles of the different APOBEC3G variants showed that there is a strong association between the minor genetic variants, genotype of the three SNPs, and HIV-1 status. Haplotype analysis demonstrated that rs6001417, rs8177832, and rs35228531 are in linkage disequilibrium. The haplotype GGT from the rs6001417, rs8177832 and rs35228531 respectively has a protective effect OR = 0.54 [0.43-0.68] with P<0.001. There was also associations between the haplotypes GGC OR = 1.6 [1.1;-2.3] P<0.05, and CGC OR = 5.21 [2.4-11.3] P<0.001, which increase the risk of infection by HIV-1 from almost two (2) to five (5) fold. This study demonstrates an association of rs6001417, rs8177832, and rs35228531 of APOBEC3G with HIV-1 infection in a population from Burkina Faso.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Compaore, TR
Soubeiga, ST
Ouattara, AK
Obiri-Yeboah, D
Tchelougou, D
Maiga, M
Assih, M
Bisseye, C
Bakouan, D
Compaore, IP
Dembele, A
Martinson, Jjmartins@pitt.eduJMARTINS
Simpore, J
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorPaxton, William A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 7 January 2016
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: PLoS ONE
Volume: 11
Number: 1
DOI or Unique Handle: 10.1371/journal.pone.0146386
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Infectious Diseases and Microbiology
Refereed: Yes
Date Deposited: 23 Aug 2016 14:56
Last Modified: 23 Jun 2018 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/28320

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