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Safety of oral amphetamine administered during positron emission tomography scans in medically screened humans

Weidner, LD and Paris, A and Frankle, WG and Narendran, R (2015) Safety of oral amphetamine administered during positron emission tomography scans in medically screened humans. PLoS ONE, 10 (12).

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Abstract

© 2015 Weidner et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Changes in endogenous dopamine levels can be detected in humans using positron emission tomography scans by measuring the amount by which a specific D2/3 radioligand is displaced. In some cases, a challenge drug such as amphetamine is introduced to increase the amount of dopamine released into the synaptic cleft. Although intravenous amphetamine is often utilized, oral amphetamine has been shown to be just as effective in increasing endogenous dopamine levels. Based on our own use of oral amphetamine as a challenge drug, we have retroactively reviewed our study charts to determine the cardiovascular safety of 0.5 mg kg-1 oral d-amphetamine. Of 172 amphetamine administrations in 144 individuals, only 2.8% of subjects experienced any transient adverse effects. In addition, we found no clinically relevant differences in increases of vital signs between healthy controls and patients. We therefore reaffirm the safety of 0.5 mg kg-1 oral amphetamine in subjects previously screened for cardiovascular risk factors.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Weidner, LD
Paris, A
Frankle, WG
Narendran, Rran29@pitt.eduRAN29
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorLe Foll, BernardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 1 December 2015
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: PLoS ONE
Volume: 10
Number: 12
DOI or Unique Handle: 10.1371/journal.pone.0140647
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Psychiatry
School of Medicine > Radiology
Refereed: Yes
Date Deposited: 23 Aug 2016 14:54
Last Modified: 30 Oct 2017 23:55
URI: http://d-scholarship.pitt.edu/id/eprint/28325

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