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The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC Collaboration

Sachdev, PS and Lipnicki, DM and Kochan, NA and Crawford, JD and Thalamuthu, A and Andrews, G and Brayne, C and Matthews, FE and Stephan, BCM and Lipton, RB and Katz, MJ and Ritchie, K and Carrière, I and Ancelin, ML and Lam, LCW and Wong, CHY and Fung, AWT and Guaita, A and Vaccaro, R and Davin, A and Ganguli, M and Dodge, H and Hughes, T and Anstey, KJ and Cherbuin, N and Butterworth, P and Ng, TP and Gao, Q and Reppermund, S and Brodaty, H and Schupf, N and Manly, J and Stern, Y and Lobo, A and Lopez-Anton, R and Santabárbara, J and Zimmerman, M and Derby, C and Leung, GTY and Chan, WC and Polito, L and Abbondanza, S and Valle, E and Colombo, M and Vitali, SF and Fossi, S and Zaccaria, D and Forloni, G and Villani, S and Christensen, H and MacKinnon, A and Easteal, S and Jacomb, T and Maxwell, K and Bowman, A and Burns, K and Broe, A and Dekker, J and Dooley, L and De Permentier, M and Fairjones, S and Fletcher, J and French, T and Foster, C and Nugent-Cleary-Fox, E and Gooi, C and Harvey, E and Helyer, R and Hsieh, S and Hughes, L and Jacek, S and Johnston, M and McCade, D and Meeth, S and Milne, E and Moir, A and O'Grady, R and Pfaeffli, K and Pose, C and Reuser, L and Rose, A and Schofield, P and Shahnawaz, Z and Sharpley, A and Thompson, C and Queisser, W and Wong, S and Mayeux, R and Brickman, A and Luchsinger, J and Sanchez, D and Tang, MX and Andrews, H and Marcos, G and De-La-Cámara, C and Saz, P and Ventura, T and Quintanilla, MA and Lobo, E (2015) The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC Collaboration. PLoS ONE, 10 (11).

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Background Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). Methods Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment. Results The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01). Conclusion Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Sachdev, PS
Lipnicki, DM
Kochan, NA
Crawford, JD
Thalamuthu, A
Andrews, G
Brayne, C
Matthews, FE
Stephan, BCM
Lipton, RB
Katz, MJ
Ritchie, K
Carrière, I
Ancelin, ML
Lam, LCW
Wong, CHY
Fung, AWT
Guaita, A
Vaccaro, R
Davin, A
Ganguli, Mgangulim@pitt.eduGANGULIM
Dodge, H
Hughes, T
Anstey, KJ
Cherbuin, N
Butterworth, P
Ng, TP
Gao, Q
Reppermund, S
Brodaty, H
Schupf, N
Manly, J
Stern, Y
Lobo, A
Lopez-Anton, R
Santabárbara, J
Zimmerman, M
Derby, C
Leung, GTY
Chan, WC
Polito, L
Abbondanza, S
Valle, E
Colombo, M
Vitali, SF
Fossi, S
Zaccaria, D
Forloni, G
Villani, S
Christensen, H
MacKinnon, A
Easteal, S
Jacomb, T
Maxwell, K
Bowman, A
Burns, K
Broe, A
Dekker, J
Dooley, L
De Permentier, M
Fairjones, S
Fletcher, J
French, T
Foster, C
Nugent-Cleary-Fox, E
Gooi, C
Harvey, E
Helyer, R
Hsieh, S
Hughes, L
Jacek, S
Johnston, M
McCade, D
Meeth, S
Milne, E
Moir, A
O'Grady, R
Pfaeffli, K
Pose, C
Reuser, L
Rose, A
Schofield, P
Shahnawaz, Z
Sharpley, A
Thompson, C
Queisser, W
Wong, S
Mayeux, R
Brickman, A
Luchsinger, J
Sanchez, D
Tang, MX
Andrews, H
Marcos, G
De-La-Cámara, C
Saz, P
Ventura, T
Quintanilla, MA
Lobo, E
ContributionContributors NameEmailPitt UsernameORCID
Date: 5 November 2015
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: PLoS ONE
Volume: 10
Number: 11
DOI or Unique Handle: 10.1371/journal.pone.0142388
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Epidemiology
School of Medicine > Neurology
School of Medicine > Psychiatry
Refereed: Yes
Date Deposited: 23 Aug 2016 14:44
Last Modified: 30 Mar 2021 14:55


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