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Inter-slice blood flow and magnetization transfer effects as a new simultaneous imaging strategy

Han, PK and Barker, JW and Kim, KH and Choi, SH and Bae, KT and Park, SH (2015) Inter-slice blood flow and magnetization transfer effects as a new simultaneous imaging strategy. PLoS ONE, 10 (10).

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Copyright © 2015 Han et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The recent blood flow and magnetization transfer (MT) technique termed alternate ascending/ descending directional navigation (ALADDIN) achieves the contrast using interslice blood flow and MT effects with no separate preparation RF pulse, thereby potentially overcoming limitations of conventional methods. In this study, we examined the signal characteristics of ALADDIN as a simultaneous blood flow and MT imaging strategy, by comparing it with pseudo-continuous ASL (pCASL) and conventional MT asymmetry (MTA) methods, all of which had the same bSSFP readout. Bloch-equation simulations and experiments showed ALADDIN perfusion signals increased with flip angle, whereas MTA signals peaked at flip angle around 45°-60°. ALADDIN provided signals comparable to those of pCASL and conventional MTA methods emulating the first, second, and third prior slices of ALADDIN under the same scan conditions, suggesting ALADDIN signals to be superposition of signals from multiple labeling planes. The quantitative cerebral blood flow signals from a modified continuous ASL model overestimated the perfusion signals compared to those measured with a pulsed ASL method. Simultaneous mapping of blood flow, MTA, and MT ratio in the whole brain is feasible with ALADDIN within a clinically reasonable time, which can potentially help diagnosis of various diseases.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Han, PK
Barker, JW
Kim, KH
Choi, SH
Bae, KTktb4@pitt.eduKTB4
Park, SH
Date: 14 October 2015
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: PLoS ONE
Volume: 10
Number: 10
DOI or Unique Handle: 10.1371/journal.pone.0140560
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Radiology
Swanson School of Engineering > Bioengineering
Refereed: Yes
Date Deposited: 23 Aug 2016 14:43
Last Modified: 23 Jun 2018 13:59


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