Needs assessment for research use of high- throughput sequencing at a large academic medical center

Geskin, A and Legowski, E and Chakka, A and Chandran, UR and Barmada, MM and LaFramboise, WA and Berg, J and Jacobson, RS (2015) Needs assessment for research use of high- throughput sequencing at a large academic medical center. PLoS ONE, 10 (6).

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Abstract

Next Generation Sequencing (NGS) methods are driving profound changes in biomedical research, with a growing impact on patient care. Many academic medical centers are evaluating potential models to prepare for the rapid increase in NGS information needs. This study sought to investigate (1) how and where sequencing data is generated and analyzed, (2) research objectives and goals for NGS, (3) workforce capacity and unmet needs, (4) storage capacity and unmet needs, (5) available and anticipated funding resources, and (6) future challenges. As a precursor to informed decision making at our institution, we undertook a systematic needs assessment of investigators using survey methods. We recruited 331 investigators from over 60 departments and divisions at the University of Pittsburgh Schools of Health Sciences and had 140 respondents, or a 42% response rate. Results suggest that both sequencing and analysis bottlenecks currently exist. Significant educational needs were identified, including both investigator-focused needs, such as selection of NGS methods suitable for specific research objectives, and program-focused needs, such as support for training an analytic workforce. The absence of centralized infrastructure was identified as an important institutional gap. Key principles for organizations managing this change were formulated based on the survey responses. This needs assessment provides an in-depth case study which may be useful to other academic medical centers as they identify and plan for future needs.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Geskin, A Legowski, E Chakka, A abc46@pitt.edu ABC46 Chandran, UR chandran@pitt.edu CHANDRAN Barmada, MM barmada@pitt.edu BARMADA LaFramboise, WA wal9@pitt.edu WAL9 0000-0002-6024-810X Berg, J jberg@pitt.edu JBERG Jacobson, RS crwlyr@pitt.edu CRWLYR
Contributors:	Contribution Contributors Name Email Pitt Username ORCID Editor Antoniewski, Christophe UNSPECIFIED UNSPECIFIED UNSPECIFIED
Centers:	Other Centers, Institutes, Offices, or Units > Pittsburgh Cancer Institute
Date:	26 June 2015
Date Type:	Publication
Access Restriction:	No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title:	PLoS ONE
Volume:	10
Number:	6
DOI or Unique Handle:	10.1371/journal.pone.0131166
Institution:	University of Pittsburgh
Schools and Programs:	School of Public Health > Human Genetics School of Medicine > Biomedical Informatics School of Medicine > Medicine
Refereed:	Yes
Date Deposited:	23 Aug 2016 14:20
Last Modified:	30 Mar 2021 13:56
URI:	http://d-scholarship.pitt.edu/id/eprint/28426

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