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Where you live may make you old: The association between perceived poor neighborhood quality and leukocyte telomere length

Park, M and Verhoeven, JE and Cuijpers, P and Reynolds, CF and Penninx, BWJH (2015) Where you live may make you old: The association between perceived poor neighborhood quality and leukocyte telomere length. PLoS ONE, 10 (6).

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Abstract

© 2015 Park et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: Strong evidence supports that living in disadvantaged neighborhoods has direct unfavorable impact on mental and physical health. However, whether it also has direct impact on cellular health is largely unknown. Thus we examined whether neighborhood quality was associated with leukocyte telomere length, an indicator of cellular aging. Methods: In May 2014, we extracted and analyzed baseline data from the Netherlands Study of Depression and Anxiety (NESDA), a large epidemiological study of individuals age between 18-65 years (n=2902). Telomere length was determined using quantitative polymerase chain reaction. Neighborhood quality was assessed using modified measures of perceived neighborhood disorder, fear of crime, and noise. We used multivariable linear regression models to examine association between perceived neighborhood quality and telomere length with comprehensive adjustment for individual and community characteristics related to socioeconomic and demographic status, urbanization level, mental and physical health, and lifestyle. Results: Compared to individuals who reported good neighborhood quality, the mean telomere length of those who reported moderate neighborhood quality was approximately 69 base pair shorter (β =-69.33, 95% CI: -119.49, -19.17, p= 0.007), and that of those who reported poor neighborhood quality were 174 base pair shorter (β =-173.80, 95% CI: -298.80, -49.01, p=0.006). For illustrative purposes, one could extrapolate these outcomes to 8.7 and 11.9 years in chronological age, respectively. Conclusion: We have established an association between perceived neighborhood quality and cellular aging over and above a range of individual attributes. Biological aging processes may be impacted by socioeconomic milieu.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Park, Mparkm@pitt.eduPARKM
Verhoeven, JE
Cuijpers, P
Reynolds, CFchipr@pitt.eduCHIPR
Penninx, BWJH
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorSaretzki, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 17 June 2015
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: PLoS ONE
Volume: 10
Number: 6
DOI or Unique Handle: 10.1371/journal.pone.0128460
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Behavioral and Community Health Sciences
School of Medicine > Psychiatry
Refereed: Yes
Date Deposited: 28 Jun 2016 16:34
Last Modified: 23 Jun 2018 11:56
URI: http://d-scholarship.pitt.edu/id/eprint/28441

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