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Accounting for dynamic fluctuations across time when examining fMRI test-retest reliability: Analysis of a reward paradigm in the EMBARC study

Chase, HW and Fournier, JC and Greenberg, T and Almeida, JR and Stiffler, R and Zevallos, CR and Aslam, H and Cooper, C and Deckersbach, T and Weyandt, S and Adams, P and Toups, M and Carmody, T and Oquendo, MA and Peltier, S and Fava, M and McGrath, PJ and Weissman, M and Parsey, R and McInnis, MG and Kurian, B and Trivedi, MH and Phillips, ML (2015) Accounting for dynamic fluctuations across time when examining fMRI test-retest reliability: Analysis of a reward paradigm in the EMBARC study. PLoS ONE, 10 (5).

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Abstract

© 2015 Chase et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Longitudinal investigation of the neural correlates of reward processing in depression may represent an important step in defining effective biomarkers for antidepressant treatment outcome prediction, but the reliability of reward-related activation is not well understood. Thirty-seven healthy control participants were scanned using fMRI while performing a reward-related guessing task on two occasions, approximately one week apart. Two main contrasts were examined: right ventral striatum (VS) activation fMRI BOLD signal related to signed prediction errors (PE) and reward expectancy (RE). We also examined bilateral visual cortex activation coupled to outcome anticipation. Significant VS PE-related activity was observed at the first testing session, but at the second testing session, VS PE-related activation was significantly reduced. Conversely, significant VS RE-related activity was observed at time 2 but not time 1. Increases in VS RE-related activity from time 1 to time 2 were significantly associated with decreases in VS PE-related activity from time 1 to time 2 across participants. Intraclass correlations (ICCs) in VS were very low. By contrast, visual cortex activation had much larger ICCs, particularly in individuals with high quality data. Dynamic changes in brain activation are widely predicted, and failure to account for these changes could lead to inaccurate evaluations of the reliability of functional MRI signals. Conventional measures of reliability cannot distinguish between changes specified by algorithmic models of neural function and noisy signal. Here, we provide evidence for the former possibility: reward-related VS activations follow the pattern predicted by temporal difference models of reward learning but have low ICCs.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Chase, HWhwc2@pitt.eduHWC2
Fournier, JCjcf48@pitt.eduJCF48
Greenberg, Ttsg15@pitt.eduTSG15
Almeida, JR
Stiffler, R
Zevallos, CR
Aslam, H
Cooper, C
Deckersbach, T
Weyandt, S
Adams, P
Toups, M
Carmody, T
Oquendo, MA
Peltier, S
Fava, M
McGrath, PJ
Weissman, M
Parsey, R
McInnis, MG
Kurian, B
Trivedi, MH
Phillips, ML
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorJaencke, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 11 May 2015
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: PLoS ONE
Volume: 10
Number: 5
DOI or Unique Handle: 10.1371/journal.pone.0126326
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Psychiatry
Refereed: Yes
Date Deposited: 23 Aug 2016 14:09
Last Modified: 01 Jul 2019 14:01
URI: http://d-scholarship.pitt.edu/id/eprint/28479

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