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Weaker dental enamel explains dental decay

Vieira, AR and Gibson, CW and Deeley, K and Xue, H and Li, Y (2015) Weaker dental enamel explains dental decay. PLoS ONE, 10 (4).

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Dental caries continues to be the most prevalent bacteria-mediated non-contagious disease of humankind. Dental professionals assert the disease can be explained by poor oral hygiene and a diet rich in sugars but this does not account for caries free individuals exposed to the same risk factors. In order to test the hypothesis that amount of amelogenin during enamel development can influence caries susceptibility, we generated multiple strains of mice with varying levels of available amelogenin during dental development. Mechanical tests showed that dental enamel developed with less amelogenin is "weaker" while the dental enamel of animals over-expressing amelogenin appears to be more resistant to acid dissolution.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Vieira, ARarv11@pitt.eduARV11
Gibson, CW
Deeley, Kkbd1@pitt.eduKBD1
Xue, H
Li, Y
ContributionContributors NameEmailPitt UsernameORCID
Date: 17 April 2015
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: PLoS ONE
Volume: 10
Number: 4
DOI or Unique Handle: 10.1371/journal.pone.0124236
Institution: University of Pittsburgh
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
Date Deposited: 23 Aug 2016 14:03
Last Modified: 02 Apr 2021 22:55


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