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Commentary: Sex difference differences? A reply to Constantino Dr Meng-Chuan Lai

Messinger, DS and Young, GS and Webb, SJ and Ozonoff, S and Bryson, SE and Carter, A and Carver, L and Charman, T and Chawarska, K and Curtin, S and Dobkins, K and Hertz-Picciotto, I and Hutman, T and Iverson, JM and Landa, R and Nelson, CA and Stone, WL and Tager-Flusberg, H and Zwaigenbaum, L (2016) Commentary: Sex difference differences? A reply to Constantino Dr Meng-Chuan Lai. Molecular Autism, 7 (1).

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Messinger et al. found a 3.18 odds ratio of male to female ASD recurrence in 1241 prospectively followed high-risk (HR) siblings. Among high-risk siblings (with and without ASD), as well as among 583 low-risk controls, girls exhibited higher performance on the Mullen Scales of Early Learning, as well as lower restricted and repetitive behavior severity scores on the Autism Diagnostic Observation Schedule (ADOS) than boys. That is, female-favoring sex differences in developmental performance and autism traits were evident among low-risk and non-ASD high-risk children, as well as those with ASD. Constantino (Mol Autism) suggests that sex differences in categorical ASD outcomes in Messinger et al. should be understood as a female protective effect. We are receptive to Constantino's (Mol Autism) suggestion, and propose that quantitative sex differences in autism-related features are keys to understanding this female protective effect.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Messinger, DS
Young, GS
Webb, SJ
Ozonoff, S
Bryson, SE
Carter, A
Carver, L
Charman, T
Chawarska, K
Curtin, S
Dobkins, K
Hertz-Picciotto, I
Hutman, T
Iverson, JMjiverson@pitt.eduJIVERSON
Landa, R
Nelson, CA
Stone, WL
Tager-Flusberg, H
Zwaigenbaum, L
Date: 29 June 2016
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Molecular Autism
Volume: 7
Number: 1
DOI or Unique Handle: 10.1186/s13229-016-0093-9
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Refereed: Yes
Article Type: Review
Date Deposited: 25 Jul 2016 13:53
Last Modified: 30 Mar 2021 13:55


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