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Molecular mechanisms regulating formation, trafficking and processing of annular gap junctions

Falk, MM and Bell, CL and Kells Andrews, RM and Murray, SA (2016) Molecular mechanisms regulating formation, trafficking and processing of annular gap junctions. BMC Cell Biology, 17 (1).

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Abstract

© 2016 Falk et al. Internalization of gap junction plaques results in the formation of annular gap junction vesicles. The factors that regulate the coordinated internalization of the gap junction plaques to form annular gap junction vesicles, and the subsequent events involved in annular gap junction processing have only relatively recently been investigated in detail. However it is becoming clear that while annular gap junction vesicles have been demonstrated to be degraded by autophagosomal and endo-lysosomal pathways, they undergo a number of additional processing events. Here, we characterize the morphology of the annular gap junction vesicle and review the current knowledge of the processes involved in their formation, fission, fusion, and degradation. In addition, we address the possibility for connexin protein recycling back to the plasma membrane to contribute to gap junction formation and intercellular communication. Information on gap junction plaque removal from the plasma membrane and the subsequent processing of annular gap junction vesicles is critical to our understanding of cell-cell communication as it relates to events regulating development, cell homeostasis, unstable proliferation of cancer cells, wound healing, changes in the ischemic heart, and many other physiological and pathological cellular phenomena.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Falk, MM
Bell, CLclb206@pitt.eduCLB206
Kells Andrews, RM
Murray, SAsmurray@pitt.eduSMURRAY
Date: 24 May 2016
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: BMC Cell Biology
Volume: 17
Number: 1
DOI or Unique Handle: 10.1186/s12860-016-0087-7
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Cell Biology and Molecular Physiology
Refereed: Yes
Article Type: Review
Date Deposited: 22 Jul 2016 19:18
Last Modified: 05 Feb 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/28666

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