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Organization, evolution and functions of the human and mouse Ly6/uPAR family genes

Loughner, CL and Bruford, EA and McAndrews, MS and Delp, EE and Swamynathan, S and Swamynathan, SK (2016) Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Human genomics, 10. 10 - ?.

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Abstract

Members of the lymphocyte antigen-6 (Ly6)/urokinase-type plasminogen activator receptor (uPAR) superfamily of proteins are cysteine-rich proteins characterized by a distinct disulfide bridge pattern that creates the three-finger Ly6/uPAR (LU) domain. Although the Ly6/uPAR family proteins share a common structure, their expression patterns and functions vary. To date, 35 human and 61 mouse Ly6/uPAR family members have been identified. Based on their subcellular localization, these proteins are further classified as GPI-anchored on the cell membrane, or secreted. The genes encoding Ly6/uPAR family proteins are conserved across different species and are clustered in syntenic regions on human chromosomes 8, 19, 6 and 11, and mouse Chromosomes 15, 7, 17, and 9, respectively. Here, we review the human and mouse Ly6/uPAR family gene and protein structure and genomic organization, expression, functions, and evolution, and introduce new names for novel family members.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Loughner, CLcll84@pitt.eduCLL84
Bruford, EA
McAndrews, MS
Delp, EE
Swamynathan, Ssus46@pitt.eduSUS46
Swamynathan, SKsks47@pitt.eduSKS470000-0002-9158-1511
Centers: Other Centers, Institutes, or Units > McGowan Institute for Regenerative Medicine
Date: 21 April 2016
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Human genomics
Volume: 10
Page Range: 10 - ?
DOI or Unique Handle: 10.1186/s40246-016-0074-2
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Cell Biology
School of Medicine > Ophthalmology
Refereed: Yes
Article Type: Review
Date Deposited: 22 Jul 2016 18:18
Last Modified: 26 Jan 2019 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/28680

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