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New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics

He, M and Zhou, Z and Shah, AA and Hong, Y and Chen, Q and Wan, Y (2016) New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics. Cell Division, 11 (1).

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Abstract

© 2016 He et al. PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of signaling proteins, facilitating the initiation, amplification and transduction of signaling. Accumulating evidence suggest that several key signaling molecules in Hippo signaling pathway are tightly regulated by various types of PTMs. Malfunction of these critical signaling modules such as YAP/TAZ, MAT1/2 and LATS1/2 due to deregulated PTMs has been linked to a variety of human diseases such as cancer. In this review article, we summarized the current understanding of the impact of PTMs in regulating Hippo signaling pathway and further discussed the potential therapeutic intervention from the view of PTMs and Hippo pathway.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
He, M
Zhou, Zzhz36@pitt.eduZHZ36
Shah, AA
Hong, Yyhong@pitt.eduYHONG
Chen, Q
Wan, Yyow4@pitt.eduYOW4
Centers: Other Centers, Institutes, or Units > Hillman Cancer Center
Other Centers, Institutes, or Units > Pittsburgh Cancer Institute
Date: 31 March 2016
Date Type: Publication
Journal or Publication Title: Cell Division
Volume: 11
Number: 1
DOI or Unique Handle: 10.1186/s13008-016-0013-6
Schools and Programs: School of Medicine > Cell Biology
Refereed: Yes
Article Type: Review
Date Deposited: 23 Aug 2016 13:37
Last Modified: 29 Jan 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/28698

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