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Inhibition of cancer cell growth by ruthenium complexes

Iida, J and Bell-Loncella, ET and Purazo, ML and Lu, Y and Dorchak, J and Clancy, R and Slavik, J and Cutler, ML and Shriver, CD (2016) Inhibition of cancer cell growth by ruthenium complexes. Journal of Translational Medicine, 14 (1).

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Background: Previous studies suggest that certain transition metal complexes, such as cisplatin, are efficacious for treating various cancer types, including ovarian, lung, and breast. Methods: In order to further evaluate ruthenium (Ru) complexes as potential anti-cancer agents, we synthesized and evaluated Ru-arene complexes. Two complexes with the general formula [Ru (n 6-p-cym) (N-N) Cl]+ were tested for their abilities to inhibit cancer cells. Results: The complex with o-phenylenediamine as the N-N ligand (o-PDA) significantly inhibited growth of breast (MDA-MB-231, MCF-7, SKBR-3, and SUM149), lymphoma (Raji), melanoma (Bowes), and osteosarcoma (HT1080); however, the complex with o-benzoquinonediimine (o-BQDI) was ineffective except for SUM149. In contrast, o-PDA failed to inhibit growth of human breast epithelial cells, MCF-10A. Treatment of MDA-MBA-231 cells with o-PDA resulted in a significant reduction of productions of PDGF-AA, GM-CSF, and VEGF-A proteins at the transcriptional levels. Finally, we demonstrated that o-PDA synergistically inhibited MDA-MB-231 cell growth with cyclophosphamide but not doxorubicin or paclitaxel. Conclusion: These results suggest that Ru-arene complexes are promising anti-cancer drugs that inhibit progression and metastasis by blocking multiple processes for breast and other types of cancer.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Iida, J
Bell-Loncella, ETetbell@pitt.eduETBELL
Purazo, ML
Lu, Yyil84@pitt.eduYIL84
Dorchak, J
Clancy, R
Slavik, J
Cutler, ML
Shriver, CD
Date: 12 February 2016
Date Type: Publication
Journal or Publication Title: Journal of Translational Medicine
Volume: 14
Number: 1
DOI or Unique Handle: 10.1186/s12967-016-0797-9
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
University of Pittsburgh at Johnstown
Refereed: Yes
Date Deposited: 22 Aug 2016 17:40
Last Modified: 19 Jun 2021 10:55


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