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The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients

Chen, X and Spaeth, RB and Freeman, SG and Scarborough, DM and Hashmi, JA and Wey, HY and Egorova, N and Vangel, M and Mao, J and Wasan, AD and Edwards, RR and Gollub, RL and Kong, J (2015) The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients. Molecular pain, 11. 67 - ?.

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Abstract

UNLABELLED: Recent advances in brain imaging have contributed to our understanding of the neural activity associated with acupuncture treatment. In this study, we investigated functional connectivity across longitudinal acupuncture treatments in older patients with knee osteoarthritis (OA). Over a period of 4 weeks (six treatments), we collected resting state functional magnetic resonance imaging (fMRI) scans from 30 patients before and after their first, third and sixth treatments. Clinical outcome showed a significantly greater pain subscore on the Knee Injury and Osteoarthritis Outcome Score (KOOS) (indicative of improvement) with verum acupuncture than with sham acupuncture. Independent component analysis (ICA) of the resting state fMRI data showed that the right frontoparietal network (rFPN) and the executive control network (ECN) showed enhanced functional connectivity (FC) with the rostral anterior cingulate cortex/medial prefrontal cortex, a key region in the descending pain modulatory system, in the verum groups as compared to the sham group after treatments. We also found that the rFPN connectivity with the left insula is (1) significantly associated with changes in KOOS pain score after treatments, and (2) significantly enhanced after verum acupuncture treatments as compared to sham treatment. Analysis of the acupuncture needle stimulation scan showed that compared with sham treatment, verum acupuncture activated the left operculum/insula, which also overlaps with findings observed in resting state analysis. Our results suggest that acupuncture may achieve its therapeutic effect on knee OA pain by modulating functional connectivity between the rFPN, ECN and the descending pain modulatory pathway. CLINICAL TRIAL NUMBER: NCT01079390.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Chen, X
Spaeth, RB
Freeman, SG
Scarborough, DM
Hashmi, JA
Wey, HY
Egorova, N
Vangel, M
Mao, J
Wasan, ADadw63@pitt.eduADW63
Edwards, RR
Gollub, RL
Kong, J
Date: 29 October 2015
Date Type: Publication
Journal or Publication Title: Molecular pain
Volume: 11
Page Range: 67 - ?
DOI or Unique Handle: 10.1186/s12990-015-0071-9
Schools and Programs: School of Medicine > Anesthesiology
School of Medicine > Psychiatry
Refereed: Yes
Date Deposited: 09 Aug 2016 20:10
Last Modified: 24 Jan 2018 08:55
URI: http://d-scholarship.pitt.edu/id/eprint/29053

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