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Implications of circadian rhythm and stress in addiction vulnerability

Becker-Krail, Darius and McClung, Colleen (2016) Implications of circadian rhythm and stress in addiction vulnerability. F1000Research, 5. 59 - 59.

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Abstract

<ns4:p>In the face of chronic stress, some individuals can maintain normal function while others go on to develop mental illness. Addiction, affecting one in every twelve people in America, is a substance use disorder long associated with stressful life events and disruptions in the sleep/wake cycle. The circadian and stress response systems have evolved to afford adaptability to environmental changes and allow for maintenance of functional stability, or homeostasis. This mini-review will discuss how circadian rhythms and stress individually affect drug response, affect each other, and how their interactions may regulate reward-related behavior. In particular, we will focus on the interactions between the circadian clock and the regulation of glucocorticoids by the hypothalamic-pituitary-adrenal (HPA) axis. Determining how these two systems act on dopaminergic reward circuitry may not only reveal the basis for vulnerability to addiction, but may also illuminate potential therapeutic targets for future investigation.</ns4:p>

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Becker-Krail, Darius
McClung, Colleenmcclungc@pitt.eduMCCLUNGC
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
ReviewerPantazopoulos, HarryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
ReviewerBukhari, SyedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
ReviewerNelson, RandyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
ReviewerBorniger, JeremyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 13 January 2016
Date Type: Publication
Journal or Publication Title: F1000Research
Volume: 5
Publisher: F1000 Research Ltd
Page Range: 59 - 59
DOI or Unique Handle: 10.12688/f1000research.7608.1
Schools and Programs: School of Medicine > Psychiatry
Refereed: Yes
Date Deposited: 09 Aug 2016 19:54
Last Modified: 05 Aug 2020 00:55
URI: http://d-scholarship.pitt.edu/id/eprint/29131

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