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MEG-based neurofeedback for hand rehabilitation

Foldes, ST and Weber, DJ and Collinger, JL (2015) MEG-based neurofeedback for hand rehabilitation. Journal of NeuroEngineering and Rehabilitation, 12 (1).

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Abstract

© 2015 Foldes et al. Background: Providing neurofeedback (NF) of motor-related brain activity in a biologically-relevant and intuitive way could maximize the utility of a brain-computer interface (BCI) for promoting therapeutic plasticity. We present a BCI capable of providing intuitive and direct control of a video-based grasp. Methods: Utilizing magnetoencephalography's (MEG) high temporal and spatial resolution, we recorded sensorimotor rhythms (SMR) that were modulated by grasp or rest intentions. SMR modulation controlled the grasp aperture of a stop motion video of a human hand. The displayed hand grasp position was driven incrementally towards a closed or opened state and subjects were required to hold the targeted position for a time that was adjusted to change the task difficulty. Results: We demonstrated that three individuals with complete hand paralysis due to spinal cord injury (SCI) were able to maintain brain-control of closing and opening a virtual hand with an average of 63 % success which was significantly above the average chance rate of 19 %. This level of performance was achieved without pre-training and less than 4 min of calibration. In addition, successful grasp targets were reached in 1.96 ± 0.15 s. Subjects performed 200 brain-controlled trials in approximately 30 min excluding breaks. Two of the three participants showed a significant improvement in SMR indicating that they had learned to change their brain activity within a single session of NF. Conclusions: This study demonstrated the utility of a MEG-based BCI system to provide realistic, efficient, and focused NF to individuals with paralysis with the goal of using NF to induce neuroplasticity.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Foldes, STstf19@pitt.eduSTF19
Weber, DJdougweber@pitt.eduDJW500000-0002-9782-3497
Collinger, JLcollinger@pitt.eduCOLLINGR
Date: 22 September 2015
Date Type: Publication
Journal or Publication Title: Journal of NeuroEngineering and Rehabilitation
Volume: 12
Number: 1
DOI or Unique Handle: 10.1186/s12984-015-0076-7
Schools and Programs: School of Medicine > Physical Medicine and Rehabilitation
Swanson School of Engineering > Bioengineering
Refereed: Yes
Date Deposited: 09 Aug 2016 16:38
Last Modified: 02 Feb 2019 16:57
URI: http://d-scholarship.pitt.edu/id/eprint/29196

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