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Combination immunotherapy: Where do we go from here?

Overacre, AE and Kurtulus, S and Sznol, M and Pardoll, DM and Anderson, A and Vignali, DAA (2015) Combination immunotherapy: Where do we go from here? Journal for ImmunoTherapy of Cancer, 3 (1).

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Abstract

© 2015 Overacre et al. The remarkable clinical success of cancer immunotherapies targeting the checkpoint receptors CTLA-4 and PD-1 has generated considerable excitement and emboldened efforts to build on this important foundation. Research efforts are now focused on understanding the mechanism of action of these immunotherapies, identifying new inhibitory mechanisms that could be targeted to achieve responses in patients with refractory cancers, and developing approaches that might exhibit efficacy against "immunologically inert" tumors. The outstanding challenges in moving forward are developing reliable strategies for determining which patients will respond optimally to a given immunotherapy, and what combination of immunotherapies and conventional therapies will prove beneficial against each tumor type. These issues were discussed in a one-day workshop at the SITC meeting in November 2014.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Overacre, AEoveracre@pitt.eduOVERACRE
Kurtulus, S
Sznol, M
Pardoll, DM
Anderson, A
Vignali, DAAdvignali@pitt.eduDVIGNALI
Date: 18 August 2015
Date Type: Publication
Journal or Publication Title: Journal for ImmunoTherapy of Cancer
Volume: 3
Number: 1
DOI or Unique Handle: 10.1186/s40425-015-0083-z
Schools and Programs: School of Medicine > Immunology
Refereed: Yes
Date Deposited: 09 Aug 2016 19:21
Last Modified: 02 Feb 2019 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/29210

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