Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Combination immunotherapy: Where do we go from here?

Overacre, AE and Kurtulus, S and Sznol, M and Pardoll, DM and Anderson, A and Vignali, DAA (2015) Combination immunotherapy: Where do we go from here? Journal for ImmunoTherapy of Cancer, 3 (1).

[img]
Preview
PDF
Published Version
Available under License : See the attached license file.

Download (395kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

The remarkable clinical success of cancer immunotherapies targeting the checkpoint receptors CTLA-4 and PD-1 has generated considerable excitement and emboldened efforts to build on this important foundation. Research efforts are now focused on understanding the mechanism of action of these immunotherapies, identifying new inhibitory mechanisms that could be targeted to achieve responses in patients with refractory cancers, and developing approaches that might exhibit efficacy against "immunologically inert" tumors. The outstanding challenges in moving forward are developing reliable strategies for determining which patients will respond optimally to a given immunotherapy, and what combination of immunotherapies and conventional therapies will prove beneficial against each tumor type. These issues were discussed in a one-day workshop at the SITC meeting in November 2014.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Overacre, AEoveracre@pitt.eduOVERACRE
Kurtulus, S
Sznol, M
Pardoll, DM
Anderson, A
Vignali, DAAdvignali@pitt.eduDVIGNALI
Date: 18 August 2015
Date Type: Publication
Journal or Publication Title: Journal for ImmunoTherapy of Cancer
Volume: 3
Number: 1
DOI or Unique Handle: 10.1186/s40425-015-0083-z
Schools and Programs: School of Medicine > Immunology
Refereed: Yes
Date Deposited: 09 Aug 2016 19:21
Last Modified: 30 Mar 2021 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/29210

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item