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Genetic ME-a visualization application for merging and editing pedigrees for genetic studies

Bui, DK and Jiang, Y and Wei, X and Ortube, MC and Weeks, DE and Conley, YP and Gorin, MB (2015) Genetic ME-a visualization application for merging and editing pedigrees for genetic studies. BMC Research Notes.

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Abstract

© 2015 Bui et al. Background: In order to study the genetics of diseases more accurately and effectively, one often collects large families. Different members of a large family may provide differing information about the structure and make-up of their pedigree. Thus, software is needed to facilitate reconciliation of pedigrees collected independently from multiple informants from a single large family to create a unified pedigree that is based on the best composite information available. Findings: Our implementation demonstrates that Genetic ME performs merging in terms of adding, replacing and combining information from two pedigrees. Through a tracking process, all of the changes made to the data set for the individuals can be traced back to their original source material. A new pedigree structure can be easily visualized while reconciling disparate information from multiple pedigrees. Methods: We developed the Genetic Merging & Editing (Genetic ME) program, an open source Java application built on top of CraneFoot and Ghostscript, to support comparing, editing and merging of pedigrees collected from multiple sources in a visually-oriented manner. Conclusions: Genetic ME constitutes an ideal addition to software packages for reconciling pedigree information from multiple sources. Genetic ME provides a friendly graphical user interface, traces the changes made by users, and produces viewable merged pedigree structures able to be further used by other popular analysis programs.


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Details

Item Type: Article
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Bui, DK
Jiang, Yyij5@pitt.eduYIJ5
Wei, X
Ortube, MC
Weeks, DEweeks@pitt.eduWEEKS0000-0001-9410-7228
Conley, YPyconley@pitt.eduYCONLEY
Gorin, MB
Date: 16 June 2015
Date Type: Publication
Journal or Publication Title: BMC Research Notes
DOI or Unique Handle: 10.1186/s13104-015-1131-y
Schools and Programs: Graduate School of Public Health > Biostatistics
Graduate School of Public Health > Human Genetics
School of Nursing > Nursing
Refereed: Yes
Date Deposited: 17 Aug 2016 13:25
Last Modified: 13 Oct 2017 23:00
URI: http://d-scholarship.pitt.edu/id/eprint/29242

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