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Molecular drivers of lobular carcinoma in situ

Logan, GJ and Dabbs, DJ and Lucas, PC and Jankowitz, RC and Brown, DD and Clark, BZ and Oesterreich, S and McAuliffe, PF (2015) Molecular drivers of lobular carcinoma in situ. Breast Cancer Research. ISSN 1465-5411

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Abstract

© 2015 Logan et al.; licensee BioMed Central.Lobular carcinoma in situ (LCIS) is considered to be a risk factor for the development of invasive breast carcinoma, but it may also be a non-obligate precursor to invasive lobular carcinoma (ILC). Many LCIS lesions do not progress to ILC, and the molecular changes that are necessary for progression from LCIS to ILC are poorly understood. Disruption in the E-cadherin complex is the hallmark of lobular lesions, but other signaling molecules, such as PIK3CA and c-src, are consistently altered in LCIS. This review focuses on the molecular drivers of lobular carcinoma, a more complete understanding of which may give perspective on which LCIS lesions progress, and which will not, thus having immense clinical implications.


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Item Type: Article
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Logan, GJlogangre@pitt.eduLOGANGRE
Dabbs, DJdjd1@pitt.eduDJD1
Lucas, PCpcl8@pitt.eduPCL8
Jankowitz, RCrcj8@pitt.eduRCJ8
Brown, DDDDB33@pitt.eduDDB33
Clark, BZ
Oesterreich, Ssto16@pitt.eduSTO16
McAuliffe, PFpfm7@pitt.eduPFM7
Centers: Other Centers, Institutes, or Units > Magee-Women's Research Institute
Other Centers, Institutes, or Units > Pittsburgh Cancer Institute
Date: 4 June 2015
Date Type: Publication
Journal or Publication Title: Breast Cancer Research
DOI or Unique Handle: 10.1186/s13058-015-0580-5
Schools and Programs: School of Medicine > Medicine
School of Medicine > Pathology
School of Medicine > Pharmacology and Chemical Biology
School of Medicine > Surgery
Refereed: Yes
ISSN: 1465-5411
Date Deposited: 16 Aug 2016 17:54
Last Modified: 30 Oct 2018 14:03
URI: http://d-scholarship.pitt.edu/id/eprint/29263

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