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Asthma and obesity: Mechanisms and clinical implications

Baffi, CW and Winnica, DE and Holguin, F (2015) Asthma and obesity: Mechanisms and clinical implications. Asthma Research and Practice, 1 (1).

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Abstract

© 2015 Baffiet al. Obesity is the most common asthma co-morbidity; it has been associated with increased risk for asthma exacerbations, worse respiratory symptoms and poor control. The exact mechanisms remain elusive and are probably multifactorial, stemming from mechanical alterations of the airways and lung parenchyma, to systemic and airway inflammatory and metabolic dysregulation that adversely influences lung function and or response to therapy. However, the fact that not every obese asthmatic is equally affected by weight gain highlights the many challenges and complexities in understanding this association. The factors that determine susceptibility may not depend on being obese alone, but rather the interactions with other phenotypical characteristics, such as age of asthma onset, gender and race to name a few. Inability to account for asthma phenotypes that are differentially affected by increasing body mass index (BMI) may contribute to the lack of consistent results across studies. This review will provide a succinct summary of obesity-related mechanisms and the clinical impact on asthma including highlights on recent progress.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Baffi, CW
Winnica, DEdew23@pitt.eduDEW23
Holguin, Ffeh9@pitt.eduFEH9
Date: 1 January 2015
Date Type: Publication
Journal or Publication Title: Asthma Research and Practice
Volume: 1
Number: 1
DOI or Unique Handle: 10.1186/s40733-015-0001-7
Schools and Programs: School of Medicine > Medicine
Refereed: Yes
Article Type: Review
Date Deposited: 16 Aug 2016 17:28
Last Modified: 05 Sep 2018 19:55
URI: http://d-scholarship.pitt.edu/id/eprint/29266

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