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Sleep and REM sleep disturbance in the pathophysiology of PTSD: The role of extinction memory

Pace-Schott, EF and Germain, A and Milad, MR (2015) Sleep and REM sleep disturbance in the pathophysiology of PTSD: The role of extinction memory. Biology of Mood and Anxiety Disorders, 5 (1).

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Abstract

© 2015 Pace-Schott et al. Post-traumatic stress disorder (PTSD) is accompanied by disturbed sleep and an impaired ability to learn and remember extinction of conditioned fear. Following a traumatic event, the full spectrum of PTSD symptoms typically requires several months to develop. During this time, sleep disturbances such as insomnia, nightmares, and fragmented rapid eye movement sleep predict later development of PTSD symptoms. Only a minority of individuals exposed to trauma go on to develop PTSD. We hypothesize that sleep disturbance resulting from an acute trauma, or predating the traumatic experience, may contribute to the etiology of PTSD. Because symptoms can worsen over time, we suggest that continued sleep disturbances can also maintain and exacerbate PTSD. Sleep disturbance may result in failure of extinction memory to persist and generalize, and we suggest that this constitutes one, non-exclusive mechanism by which poor sleep contributes to the development and perpetuation of PTSD. Also reviewed are neuroendocrine systems that show abnormalities in PTSD, and in which stress responses and sleep disturbance potentially produce synergistic effects that interfere with extinction learning and memory. Preliminary evidence that insomnia alone can disrupt sleep-dependent emotional processes including consolidation of extinction memory is also discussed. We suggest that optimizing sleep quality following trauma, and even strategically timing sleep to strengthen extinction memories therapeutically instantiated during exposure therapy, may allow sleep itself to be recruited in the treatment of PTSD and other trauma and stress-related disorders.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Pace-Schott, EF
Germain, Aang2@pitt.eduANG2
Milad, MR
Date: 1 January 2015
Date Type: Publication
Journal or Publication Title: Biology of Mood and Anxiety Disorders
Volume: 5
Number: 1
DOI or Unique Handle: 10.1186/s13587-015-0018-9
Schools and Programs: School of Medicine > Psychiatry
Refereed: Yes
Article Type: Review
Date Deposited: 16 Aug 2016 16:48
Last Modified: 02 Feb 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/29269

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