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Lymphoma of the orbit masquerading as Tolosa-Hunt syndrome Neuro-ophthalmology

Shazly, TA and Mitchell, EB and Bonhomme, GR and Schuman, JS (2015) Lymphoma of the orbit masquerading as Tolosa-Hunt syndrome Neuro-ophthalmology. BMC Ophthalmology, 15 (1).

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Background: Tolosa-Hunt syndrome is a rare clinical syndrome characterized by painful ophthalmoplegia and ipsilateral cranial neuropathies. It is caused by an inflammatory process of unknown etiology. Case presentation: We present a case of a 77-year-old white man with history of Waldenstrom's macroglobulinemia transforming to large B-cell lymphoma who presented to a community physician complaining of 4 months of isolated right retro-orbital pain and later with diplopia, ptosis, 6th nerve and pupil-sparing partial 3rd nerve palsies as well as progressive neurological findings. His clinical course was complicated by debilitating neurological symptoms and multiple hospitalizations leading to a delay in diagnosis caused by incomplete initial workup. Conclusion: This case is a reminder that lymphoproliferative disorders often mimic other neurologic disorders and that Tolosa-Hunt is a rare diagnosis that must be considered a diagnosis of exclusion.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Shazly, TATAS247@pitt.eduTAS2470000-0002-4561-1871
Mitchell, EBebm32@pitt.eduEBM32
Bonhomme, GRgrb14@pitt.eduGRB14
Schuman, JSjss28@pitt.eduJSS280000-0002-8885-3766
Date: 15 May 2015
Date Type: Publication
Journal or Publication Title: BMC Ophthalmology
Volume: 15
Number: 1
DOI or Unique Handle: 10.1186/s12886-015-0037-8
Schools and Programs: School of Medicine > Ophthalmology
Refereed: Yes
Date Deposited: 16 Aug 2016 14:42
Last Modified: 30 Mar 2021 11:55


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