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Novel approaches in the management of pancreatic ductal adenocarcinoma: Potential promises for the future

Goel, G and Sun, W (2015) Novel approaches in the management of pancreatic ductal adenocarcinoma: Potential promises for the future. Journal of Hematology and Oncology, 8 (1).

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Abstract

© 2015 Goel and Sun; licensee BioMed Central. Abstract Despite a few breakthroughs in therapy for advanced disease in the recent years, pancreatic ductal adenocarcinoma continues to remain one of the most challenging human malignancies to treat. The overall prognosis for the majority of patients with pancreatic cancer is rather dismal, and therefore, more effective treatment options are being desperately sought. The practical goals of management are to improve the cure rates for patients with resectable disease, achieve a higher conversion rate of locally advanced tumor into potentially resectable disease, and finally, prolong the overall survival for those who develop metastatic disease. Our understanding of the complex genetic alterations, the implicated molecular pathways, and the role of desmoplastic stroma in pancreatic cancer tumorigenesis has increased several folds in the recent years. This has facilitated the development of novel therapeutic strategies against pancreatic cancer, some of which are currently under evaluation in ongoing preclinical and clinical studies. This review will summarize the existing treatment approaches for this devastating disease and also discuss the promising therapeutic approaches that are currently in different stages of clinical development.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Goel, G
Sun, Wwes45@pitt.eduWES45
Centers: Other Centers, Institutes, or Units > Pittsburgh Cancer Institute
Date: 1 December 2015
Date Type: Publication
Journal or Publication Title: Journal of Hematology and Oncology
Volume: 8
Number: 1
DOI or Unique Handle: 10.1186/s13045-015-0141-5
Schools and Programs: School of Medicine > Medicine
Refereed: Yes
Date Deposited: 16 Aug 2016 14:15
Last Modified: 26 Jan 2019 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/29279

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