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Neuroprotection in acute brain injury: An up-to-date review

Stocchetti, N and Taccone, FS and Citerio, G and Pepe, PE and Roux, PD and Oddo, M and Polderman, KH and Stevens, RD and Barsan, W and Maas, AIR and Meyfroidt, G and Bell, MJ and Silbergleit, R and Vespa, PM and Faden, AI and Helbok, R and Tisherman, S and Zanier, ER and Valenzuela, T and Wendon, J and Menon, DK and Vincent, JL (2015) Neuroprotection in acute brain injury: An up-to-date review. Critical Care, 19 (1). ISSN 1364-8535

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Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Stocchetti, N
Taccone, FS
Citerio, G
Pepe, PE
Roux, PD
Oddo, M
Polderman, KHkhp5@pitt.eduKHP5
Stevens, RD
Barsan, W
Maas, AIR
Meyfroidt, G
Bell, MJ
Silbergleit, R
Vespa, PM
Faden, AI
Helbok, R
Tisherman, S
Zanier, ER
Valenzuela, T
Wendon, J
Menon, DK
Vincent, JL
Date: 21 April 2015
Date Type: Publication
Journal or Publication Title: Critical Care
Volume: 19
Number: 1
DOI or Unique Handle: 10.1186/s13054-015-0887-8
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 1364-8535
Article Type: Review
Date Deposited: 30 Aug 2016 16:21
Last Modified: 30 Mar 2021 15:55


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