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Gene-and stem cell-based therapeutics for cartilage regeneration and repair

Tang, Y and Wang, B (2015) Gene-and stem cell-based therapeutics for cartilage regeneration and repair. Stem Cell Research and Therapy, 6 (1).

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Abstract

© 2015 Tang and Wang; licensee BioMed Central. Cell-based regeneration of damaged or diseased articular cartilage still faces significant clinical challenge due to inadequate environmental regulation of stem cell proliferation and chondrogenic differentiation. The role of insulin-like growth factor in critical steps of human bone marrow-derived mesenchymal stem cell chondrogenesis has potential in optimizing the therapeutic use of mesenchymal stem cells in cartilage disorders. In addition to the previously described benefits of recombinant adeno-associated viral vector for in vivo gene therapy, demonstrated by Frisch and colleagues, such vector is also a safe and efficient delivery system for the genetic modification of human bone marrow-derived mesenchymal stem cells via ex vivo insulin-like growth factor 1 gene transfer, so that implanted mesenchymal stem cells continuously release a therapeutic level of insulin-like growth factor 1 to achieve sustained mesenchymal stem cell chondrogenesis for cartilage regeneration.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Tang, Yyit3@pitt.eduYIT3
Wang, Bbingwang@pitt.eduBINGWANG
Date: 15 April 2015
Date Type: Publication
Journal or Publication Title: Stem Cell Research and Therapy
Volume: 6
Number: 1
DOI or Unique Handle: 10.1186/s13287-015-0058-5
Schools and Programs: School of Medicine > Surgery
Refereed: Yes
Date Deposited: 30 Aug 2016 16:20
Last Modified: 06 Jul 2019 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/29378

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