Ambient ozone exposure and children's acute asthma in New York City: A case-crossover analysis Children s Environmental Health

Sheffield, PE and Zhou, J and Shmool, JLC and Clougherty, JE (2015) Ambient ozone exposure and children's acute asthma in New York City: A case-crossover analysis Children s Environmental Health. Environmental Health: A Global Access Science Source, 14 (1).

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Abstract

Background: Childhood asthma morbidity has been associated with ambient ozone in case-crossover studies. Varying effects of ozone by child age and sex, however, have been less explored. Methods: This study evaluates associations between ozone exposure and asthma emergency department visits and hospitalizations among boys and girls aged 5-17 years in New York City for the 2005-2011 warm season period. Time-stratified case-crossover analysis was conducted and, for comparison, time-series analysis controlling for season, day-of-week, same-day and delayed effects of temperature and relative humidity were also performed. Results: We found associations between ambient ozone levels and childhood asthma emergency department visits and hospitalizations in New York City, although the relationships varied among boys and girls and by age group. For an increase of interquartile range (0.013 ppm) in ozone, there was a 2.9-8.4% increased risk for boys and 5.4-6.5% for girls in asthma emergency department visits; and 8.2% increased risk for girls in hospitalizations. Among girls, we observed stronger associations among older children (10-13 and 14-17 year age groups). We did not observe significant modification by age for boys. Boys exhibited a more prompt response (lag day 1) to ozone than did girls (lag day 3), but significant associations for girls were retained longer, through lag day 6. Conclusions: Our study indicates significant variance in associations between short-term ozone concentrations and asthma events by child sex and age. Differences in ozone response for boys and girls, before and after puberty, may point towards both social (gendered) and biological (sex-linked) sources of effect modification.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Sheffield, PE Zhou, J Shmool, JLC jlcarr@pitt.edu JLCARR Clougherty, JE jcloughe@pitt.edu JCLOUGHE
Date:	1 January 2015
Date Type:	Publication
Journal or Publication Title:	Environmental Health: A Global Access Science Source
Volume:	14
Number:	1
DOI or Unique Handle:	10.1186/s12940-015-0010-2
Schools and Programs:	School of Public Health > Environmental and Occupational Health
Refereed:	Yes
Date Deposited:	31 Aug 2016 16:08
Last Modified:	30 Mar 2021 12:55
URI:	http://d-scholarship.pitt.edu/id/eprint/29392

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