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Renal angina: Concept and development of pretest probability assessment in acute kidney injury

Chawla, LS and Goldstein, SL and Kellum, JA and Ronco, C (2015) Renal angina: Concept and development of pretest probability assessment in acute kidney injury. Critical Care, 19 (1). ISSN 1364-8535

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Abstract

© Chawla et al. The context of a diagnostic test is a critical component for the interpretation of its result. This context defines the pretest probability of the diagnosis and forms the basis for the interpretation and value of adding the diagnostic test. In the field of acute kidney injury, a multitude of early diagnostic biomarkers have been developed, but utilization in the appropriate context is less well understood and has not been codified until recently. In order to better operationalize the context and pretest probability assessment for acute kidney injury diagnosis, the renal angina concept was proposed in 2010 for use in both children and adults. Renal angina has been assessed in approximately 1,000 subjects. However, renal angina as a concept is still unfamiliar to most clinicians and the rationale for introducing the term is not obvious. We therefore review the concept and development of renal angina, and the currently available data validating it. We discuss the various arguments for and against this construct. Future research testing the performance of renal angina with acute kidney injury biomarkers is warranted.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Chawla, LS
Goldstein, SL
Kellum, JAkellum@pitt.eduKELLUM0000-0003-1995-2653
Ronco, C
Date: 27 February 2015
Date Type: Publication
Journal or Publication Title: Critical Care
Volume: 19
Number: 1
DOI or Unique Handle: 10.1186/s13054-015-0779-y
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 1364-8535
Date Deposited: 01 Sep 2016 15:19
Last Modified: 04 Feb 2019 15:57
URI: http://d-scholarship.pitt.edu/id/eprint/29405

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