Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Receptor-type protein tyrosine phosphatases in cancer

Du, Y and Grandis, JR (2014) Receptor-type protein tyrosine phosphatases in cancer. Chinese Journal of Cancer, 34 (2). 61 - 69.

Published Version
Available under License : See the attached license file.

Download (472kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


Protein tyrosine phosphatases (PTPs) play an important role in regulating cell signaling events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival, migration, and invasion. Receptor-type protein tyrosine phosphatases (PTPRs) are a subgroup of PTPs that share a transmembrane domain with resulting similarities in function and target specificity. In this review, we summarize genetic and epigenetic alterations including mutation, deletion, amplification, and promoter methylation of PTPRs in cancer and consider the consequences of PTPR alterations in different types of cancers. We also summarize recent developments using PTPRs as prognostic or predictive biomarkers and/or direct targets. Increased understanding of the role of PTPRs in cancer may provide opportunities to improve therapeutic approaches.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Du, Y
Grandis, JRjgrandis@pitt.eduJGRANDIS
Date: 1 January 2014
Date Type: Publication
Journal or Publication Title: Chinese Journal of Cancer
Volume: 34
Number: 2
Page Range: 61 - 69
DOI or Unique Handle: 10.5732/cjc.014.10146
Schools and Programs: School of Medicine > Otolaryngology
School of Medicine > Pharmacology and Chemical Biology
Refereed: Yes
Article Type: Review
Date Deposited: 22 Dec 2016 15:26
Last Modified: 30 Mar 2021 13:56


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item