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Sex differences in mood disorders: Perspectives from humans and rodent models

Seney, ML and Sibille, E (2014) Sex differences in mood disorders: Perspectives from humans and rodent models. Biology of Sex Differences, 5 (1).

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Abstract

© 2014 Seney and Sibille; licensee BioMed Central Ltd. Mood disorders are devastating, often chronic illnesses characterized by low mood, poor affect, and anhedonia. Notably, mood disorders are approximately twice as prevalent in women compared to men. If sex differences in mood are due to underlying biological sex differences, a better understanding of the biology is warranted to develop better treatment or even prevention of these debilitating disorders. In this review, our goals are to: 1) summarize the literature related to mood disorders with respect to sex differences in prevalence, 2) introduce the corticolimbic brain network of mood regulation, 3) discuss strategies and challenges of modeling mood disorders in mice, 4) discuss mechanisms underlying sex differences and how these can be tested in mice, and 5) discuss how our group and others have used a translational approach to investigate mechanisms underlying sex differences in mood disorders in humans and mice.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Seney, MLmas378@pitt.eduMAS3780000-0002-6401-9494
Sibille, E
Date: 1 December 2014
Date Type: Publication
Journal or Publication Title: Biology of Sex Differences
Volume: 5
Number: 1
DOI or Unique Handle: 10.1186/s13293-014-0017-3
Schools and Programs: Dietrich School of Arts and Sciences > Neuroscience
School of Medicine > Psychiatry
Refereed: Yes
Article Type: Review
Date Deposited: 22 Dec 2016 14:59
Last Modified: 19 Dec 2020 11:56
URI: http://d-scholarship.pitt.edu/id/eprint/29442

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