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Cardiovascular magnetic resonance characterization of left ventricular non-compaction provides independent prognostic information in patients with incident heart failure or suspected cardiomyopathy

Ashrith, G and Gupta, D and Hanmer, J and Weiss, RM (2014) Cardiovascular magnetic resonance characterization of left ventricular non-compaction provides independent prognostic information in patients with incident heart failure or suspected cardiomyopathy. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 16. 64 - ?.

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Abstract

BACKGROUND: With recent advances in imaging methods, detection of LVNC is increasingly common. Concomitantly, the prognostic importance of LVNC is less clear. METHODS: We followed 42 patients (63% male, age 44 ± 15 years) with incident heart failure or suspected cardiomyopathy, in whom cardiovascular magnetic resonance (CMR) yielded a diagnosis of LVNC, for 27 ± 16 months. RESULTS: LVNC was preferentially distributed among posterolateral segments, with apical predominance. Patients with maximum non-compacted-to-compacted thickness ratio (NC:C)  <  3 improved by 0.9 ± 0.7 NYHA Class, compared to 0.3 ± 0.8 for patients with NC:C  >  3 (p = 0.001). In 29 patients with baseline LVEF  <  0.40, there was an inverse correlation between NC:C ratio, and the change in LVEF during follow-up. Tachyarrhythmias were observed in 42% of patients with LGE, and in 0% of patients without LGE (p = 0.02). In multivariate analysis, arrhythmia incidence was significantly higher in patients with LGE, even when adjusted for LVEF and RVEF. CONCLUSIONS: CMR assessments of myocardial morphology provide important prognostic information for patients with LVNC who present with incident heart failure or suspected cardiomyopathy.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Ashrith, G
Gupta, D
Hanmer, Jjzh23@pitt.eduJZH23
Weiss, RM
Date: 1 January 2014
Date Type: Publication
Journal or Publication Title: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Volume: 16
Page Range: 64 - ?
DOI or Unique Handle: 10.1186/s12968-014-0064-2
Schools and Programs: School of Medicine > Medicine
Refereed: Yes
Date Deposited: 21 Dec 2016 20:44
Last Modified: 12 Oct 2017 08:55
URI: http://d-scholarship.pitt.edu/id/eprint/29484

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