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Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer

Nadauld, LD and Garcia, S and Natsoulis, G and Bell, JM and Miotke, L and Hopmans, ES and Xu, H and Pai, RK and Palm, C and Regan, JF and Chen, H and Flaherty, P and Ootani, A and Zhang, NR and Ford, JM and Kuo, CJ and Ji, HP (2014) Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer. Genome biology, 15 (8). 428 - ?.

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Abstract

BACKGROUND: Gastric cancer is the second-leading cause of global cancer deaths, with metastatic disease representing the primary cause of mortality. To identify candidate drivers involved in oncogenesis and tumor evolution, we conduct an extensive genome sequencing analysis of metastatic progression in a diffuse gastric cancer. This involves a comparison between a primary tumor from a hereditary diffuse gastric cancer syndrome proband and its recurrence as an ovarian metastasis.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Nadauld, LD
Garcia, S
Natsoulis, G
Bell, JM
Miotke, L
Hopmans, ES
Xu, H
Pai, RKrkp18@pitt.eduRKP18
Palm, C
Regan, JF
Chen, H
Flaherty, P
Ootani, A
Zhang, NR
Ford, JM
Kuo, CJ
Ji, HP
Date: 1 January 2014
Date Type: Publication
Journal or Publication Title: Genome biology
Volume: 15
Number: 8
Page Range: 428 - ?
DOI or Unique Handle: 10.1186/s13059-014-0428-9
Schools and Programs: School of Medicine > Pathology
Refereed: Yes
Date Deposited: 19 Sep 2016 15:54
Last Modified: 30 Mar 2021 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/29499

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