Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Sugammadex is effective in reversing rocuronium in the presence of antibiotics

Hudson, ME and Rietbergen, H and Chelly, JE (2014) Sugammadex is effective in reversing rocuronium in the presence of antibiotics. BMC Anesthesiology, 14 (1).

[img]
Preview
PDF
Published Version
Available under License : See the attached license file.

Download (375kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

© 2014 Hudson et al.; licensee BioMed Central Ltd. Background: The effectiveness of sugammadex in reversing rocuronium-induced neuromuscular blockade (NMB) in the presence of drugs that may potentiate NMB remains to be fully established. The aim of this post-hoc analysis of data from a Phase III clinical trial (VISTA; NCT00298831) was to investigate the impact of antibiotics on recovery from rocuronium-induced NMB after administration of sugammadex for reversal, and compared the neuromuscular recovery in patients who received antibiotics preoperatively with those who did not.Methods: A Phase III, multicenter, open-label study designed to reflect potential use of sugammadex in clinical practice was conducted at 19 sites. Data obtained from patients who received antibiotics were compared with the cohort of patients who underwent the same protocol without antibiotics. Each subject received rocuronium 0.6 mg/kg for muscle relaxation, after which tracheal intubation was performed; patients were also permitted to receive maintenance doses of rocuronium 0.15 mg/kg to maintain the desired level of NMB throughout the operation, as required. At least 15 min after the last rocuronium dose, patients received sugammadex 4.0 mg/kg for reversal. Neuromuscular monitoring was continued until a train-of-four (TOF) ratio of ≥0.9 was achieved or the anesthetic was discontinued.Results: The presence of antibiotics prior to the administration of sugammadex did not affect the recovery time from rocuronium-induced NMB when sugammadex 4.0 mg/kg was administered at least 15 min after the last dose of rocuronium. In the presence of antibiotics, the geometric mean (95% CI) time from administration of sugammadex 4.0 mg/kg to recovery of the TOF ratio to ≥0.9 was 1.6 (1.4-1.9) min (range: 0.7-10.5 min), compared with 2.0 (1.8-2.3) min (range: 0.7-22.3 min) for patients who did not receive antibiotics.Conclusions: These findings suggest that prophylactic antibiotic use is unlikely to have a major impact on the recovery time from rocuronium-induced NMB with sugammadex reversal.Trial registration: ClinicalTrials.gov Identifier: NCT00298831.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Hudson, MEhudson@pitt.eduHUDSON
Rietbergen, H
Chelly, JEjec22@pitt.eduJEC22
Date: 15 August 2014
Date Type: Publication
Journal or Publication Title: BMC Anesthesiology
Volume: 14
Number: 1
DOI or Unique Handle: 10.1186/1471-2253-14-69
Schools and Programs: School of Medicine > Anesthesiology
Refereed: Yes
Article Type: Review
Date Deposited: 19 Sep 2016 15:55
Last Modified: 15 Oct 2017 19:55
URI: http://d-scholarship.pitt.edu/id/eprint/29500

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item