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The CD8 Antiviral Factor (CAF) can suppress HIV-1 transcription from the Long Terminal Repeat (LTR) promoter in the absence of elements upstream of the CATATAA box

Shridhar, V and Chen, Y and Gupta, P (2014) The CD8 Antiviral Factor (CAF) can suppress HIV-1 transcription from the Long Terminal Repeat (LTR) promoter in the absence of elements upstream of the CATATAA box. Virology Journal, 11 (1).

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Abstract

© 2014 Shridhar et al.; licensee BioMed Central Ltd. Background: The CD8 Antiviral Factor (CAF) suppresses viral transcription from the HIV-1 Long Terminal Repeat (LTR) promoter in a non-cytolytic manner. However, the region on the LTR upon which CAF acts is unknown. Our objective was to determine the region on the LTR upon which CAF acts to suppress HIV-1 transcription. Methods. Serial deletions of the LTR from the 5' end and inactivating point mutations were made.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Shridhar, V
Chen, YCHENY@pitt.eduCHENY
Gupta, Ppgupta1@pitt.eduPGUPTA1
Centers: Other Centers, Institutes, Offices, or Units > Magee-Women's Research Institute
Date: 21 July 2014
Date Type: Publication
Journal or Publication Title: Virology Journal
Volume: 11
Number: 1
DOI or Unique Handle: 10.1186/1743-422x-11-130
Schools and Programs: Graduate School of Public Health > Infectious Diseases and Microbiology
School of Medicine > Infectious Diseases and Microbiology
School of Medicine > Obstetrics, Gynecology, and Reproductive Sciences
Refereed: Yes
Date Deposited: 19 Sep 2016 15:24
Last Modified: 29 Jan 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/29505

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