Feng, P and Wang, X and Casado, PL and Küchler, EC and Deeley, K and Noel, J and Kimm, H and Kim, JH and Haas, AN and Quinelato, V and Bonato, LL and Granjeiro, JM and Susin, C and Vieira, AR
(2014)
Genome wide association scan for chronic periodontitis implicates novel locus.
BMC Oral Health, 14 (1).
Abstract
Background: There is evidence for a genetic contribution to chronic periodontitis. In this study, we conducted a genome wide association study among 866 participants of the University of Pittsburgh Dental Registry and DNA Repository, whose periodontal diagnosis ranged from healthy (N = 767) to severe chronic periodontitis (N = 99).Methods: Genotypingi of over half-million single nucleotide polymorphisms was determined. Analyses were done twice, first in the complete dataset of all ethnicities, and second including only samples defined as self-reported Whites. From the top 100 results, twenty single nucleotide polymorphisms had consistent results in both analyses (borderline p-values ranging from 1E-05 to 1E-6) and were selected to be tested in two independent datasets derived from 1,460 individuals from Porto Alegre, and 359 from Rio de Janeiro, Brazil. Meta-analyses of the Single nucleotide polymorphisms showing a trend for association in the independent dataset were performed.Results: The rs1477403 marker located on 16q22.3 showed suggestive association in the discovery phase and in the Porto Alegre dataset (p = 0.05). The meta-analysis suggested the less common allele decreases the risk of chronic periodontitis.Conclusions: Our data offer a clear hypothesis to be independently tested regarding the contribution of the 16q22.3 locus to chronic periodontitis. © 2014 Feng et al.; licensee BioMed Central Ltd.
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Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID |
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Feng, P | | | | Wang, X | | | | Casado, PL | | | | Küchler, EC | | | | Deeley, K | kbd1@pitt.edu | KBD1 | | Noel, J | jbn9@pitt.edu | JBN9 | | Kimm, H | | | | Kim, JH | | | | Haas, AN | | | | Quinelato, V | | | | Bonato, LL | | | | Granjeiro, JM | | | | Susin, C | | | | Vieira, AR | arv11@pitt.edu | ARV11 | |
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Date: |
9 July 2014 |
Date Type: |
Publication |
Journal or Publication Title: |
BMC Oral Health |
Volume: |
14 |
Number: |
1 |
DOI or Unique Handle: |
10.1186/1472-6831-14-84 |
Schools and Programs: |
School of Dental Medicine > Dental Science |
Refereed: |
Yes |
Date Deposited: |
19 Dec 2016 20:19 |
Last Modified: |
22 Jun 2021 13:56 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/29536 |
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