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Genome wide association scan for chronic periodontitis implicates novel locus

Feng, P and Wang, X and Casado, PL and Küchler, EC and Deeley, K and Noel, J and Kimm, H and Kim, JH and Haas, AN and Quinelato, V and Bonato, LL and Granjeiro, JM and Susin, C and Vieira, AR (2014) Genome wide association scan for chronic periodontitis implicates novel locus. BMC Oral Health, 14 (1).

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Abstract

Background: There is evidence for a genetic contribution to chronic periodontitis. In this study, we conducted a genome wide association study among 866 participants of the University of Pittsburgh Dental Registry and DNA Repository, whose periodontal diagnosis ranged from healthy (N = 767) to severe chronic periodontitis (N = 99).Methods: Genotypingi of over half-million single nucleotide polymorphisms was determined. Analyses were done twice, first in the complete dataset of all ethnicities, and second including only samples defined as self-reported Whites. From the top 100 results, twenty single nucleotide polymorphisms had consistent results in both analyses (borderline p-values ranging from 1E-05 to 1E-6) and were selected to be tested in two independent datasets derived from 1,460 individuals from Porto Alegre, and 359 from Rio de Janeiro, Brazil. Meta-analyses of the Single nucleotide polymorphisms showing a trend for association in the independent dataset were performed.Results: The rs1477403 marker located on 16q22.3 showed suggestive association in the discovery phase and in the Porto Alegre dataset (p = 0.05). The meta-analysis suggested the less common allele decreases the risk of chronic periodontitis.Conclusions: Our data offer a clear hypothesis to be independently tested regarding the contribution of the 16q22.3 locus to chronic periodontitis. © 2014 Feng et al.; licensee BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Feng, P
Wang, X
Casado, PL
Küchler, EC
Deeley, Kkbd1@pitt.eduKBD1
Noel, Jjbn9@pitt.eduJBN9
Kimm, H
Kim, JH
Haas, AN
Quinelato, V
Bonato, LL
Granjeiro, JM
Susin, C
Vieira, ARarv11@pitt.eduARV11
Date: 9 July 2014
Date Type: Publication
Journal or Publication Title: BMC Oral Health
Volume: 14
Number: 1
DOI or Unique Handle: 10.1186/1472-6831-14-84
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
Date Deposited: 19 Dec 2016 20:19
Last Modified: 20 Feb 2020 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/29536

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