Lee, CPL and Irwanto, A and Salim, A and Yuan, JM and Liu, J and Koh, WP and Hartman, M
(2014)
Breast cancer risk assessment using genetic variants and risk factors in a Singapore Chinese population.
Breast Cancer Research, 16 (3).
ISSN 1465-5411
Abstract
Introduction: Genetic variants for breast cancer risk identified in genome-wide association studies (GWAS) in Western populations require further testing in Asian populations. A risk assessment model incorporating both validated genetic variants and established risk factors may improve its performance in risk prediction of Asian women.Methods: A nested case-control study of female breast cancer (411 cases and 1,212 controls) within the Singapore Chinese Health Study was conducted to investigate the effects of 51 genetic variants identified in previous GWAS on breast cancer risk. The independent effect of these genetic variants was assessed by creating a summed genetic risk score (GRS) after adjustment for body mass index and the Gail model risk factors for breast cancer.Results: The GRS was an independent predictor of breast cancer risk in Chinese women. The multivariate-adjusted odds ratios (95% confidence intervals) of breast cancer for the second, third, and fourth quartiles of the GRS were 1.26 (0.90 to 1.76), 1.47 (1.06 to 2.04) and 1.75 (1.27 to 2.41) respectively (P for trend <0.001). In addition to established risk factors, the GRS improved the classification of 6.2% of women for their absolute risk of breast cancer in the next five years.Conclusions: Genetic variants on top of conventional risk factors can improve the risk prediction of breast cancer in Chinese women. © 2014 Lee et al.; licensee BioMed Central Ltd.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
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Lee, CPL | | | | Irwanto, A | | | | Salim, A | | | | Yuan, JM | yuanj@pitt.edu | YUANJ | | Liu, J | | | | Koh, WP | | | | Hartman, M | | | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Pittsburgh Cancer Institute |
Date: |
18 June 2014 |
Date Type: |
Publication |
Journal or Publication Title: |
Breast Cancer Research |
Volume: |
16 |
Number: |
3 |
DOI or Unique Handle: |
10.1186/bcr3678 |
Schools and Programs: |
School of Public Health > Epidemiology |
Refereed: |
Yes |
ISSN: |
1465-5411 |
Date Deposited: |
19 Dec 2016 20:18 |
Last Modified: |
29 Jan 2019 15:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/29543 |
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