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Pulmonary symptoms and diagnoses are associated with HIV in the MACS and WIHS cohorts

Gingo, MR and Balasubramani, GK and Rice, TB and Kingsley, L and Kleerup, EC and Detels, R and Seaberg, EC and Greenblatt, RM and Holman, S and Huang, L and Sutton, SH and Bertolet, M and Morris, A (2014) Pulmonary symptoms and diagnoses are associated with HIV in the MACS and WIHS cohorts. BMC Pulmonary Medicine, 14 (1).

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Abstract

Background: Several lung diseases are increasingly recognized as comorbidities with HIV; however, few data exist related to the spectrum of respiratory symptoms, diagnostic testing, and diagnoses in the current HIV era. The objective of the study is to determine the impact of HIV on prevalence and incidence of respiratory disease in the current era of effective antiretroviral treatment.Methods: A pulmonary-specific questionnaire was administered yearly for three years to participants in the Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS). Adjusted prevalence ratios for respiratory symptoms, testing, or diagnoses and adjusted incidence rate ratios for diagnoses in HIV-infected compared to HIV-uninfected participants were determined. Risk factors for outcomes in HIV-infected individuals were modeled.Results: Baseline pulmonary questionnaires were completed by 907 HIV-infected and 989 HIV-uninfected participants in the MACS cohort and by 1405 HIV-infected and 571 HIV-uninfected participants in the WIHS cohort. In MACS, dyspnea, cough, wheezing, sleep apnea, and incident chronic obstructive pulmonary disease (COPD) were more common in HIV-infected participants. In WIHS, wheezing and sleep apnea were more common in HIV-infected participants. Smoking (MACS and WIHS) and greater body mass index (WIHS) were associated with more respiratory symptoms and diagnoses. While sputum studies, bronchoscopies, and chest computed tomography scans were more likely to be performed in HIV-infected participants, pulmonary function tests were no more common in HIV-infected individuals. Respiratory symptoms in HIV-infected individuals were associated with history of pneumonia, cardiovascular disease, or use of HAART. A diagnosis of asthma or COPD was associated with previous pneumonia.Conclusions: In these two cohorts, HIV is an independent risk factor for several respiratory symptoms and pulmonary diseases including COPD and sleep apnea. Despite a higher prevalence of chronic respiratory symptoms, testing for non-infectious respiratory diseases may be underutilized in the HIV-infected population. © 2014 Gingo et al.; licensee BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Gingo, MRmrg35@pitt.eduMRG35
Balasubramani, GKBalaGK@edc.pitt.eduBKG100000-0001-7221-1825
Rice, TB
Kingsley, Lkingsley@pitt.eduKINGSLEY
Kleerup, EC
Detels, R
Seaberg, EC
Greenblatt, RM
Holman, S
Huang, L
Sutton, SH
Bertolet, Mbertoletm@edc.pitt.eduMHB120000-0002-5799-9033
Morris, A
Centers: Other Centers, Institutes, or Units > Epidemiology Data Center
Date: 30 April 2014
Date Type: Publication
Journal or Publication Title: BMC Pulmonary Medicine
Volume: 14
Number: 1
DOI or Unique Handle: 10.1186/1471-2466-14-75
Schools and Programs: Graduate School of Public Health > Epidemiology
Graduate School of Public Health > Infectious Diseases and Microbiology
School of Medicine > Immunology
School of Medicine > Medicine
Refereed: Yes
Date Deposited: 16 Dec 2016 18:45
Last Modified: 22 May 2019 12:55
URI: http://d-scholarship.pitt.edu/id/eprint/29566

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