Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Regulation of Wnt/β-catenin signaling by posttranslational modifications

Gao, C and Xiao, G and Hu, J (2014) Regulation of Wnt/β-catenin signaling by posttranslational modifications. Cell and Bioscience, 4 (1).

Published Version
Available under License : See the attached license file.

Download (1MB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


The canonical Wnt signaling pathway (or Wnt/β-catenin pathway) plays a pivotal role in embryonic development and adult homeostasis; deregulation of the Wnt pathway contributes to the initiation and progression of human diseases including cancer. Despite its importance in human biology and disease, how regulation of the Wnt/β-catenin pathway is achieved remains largely undefined. Increasing evidence suggests that post-translational modifications (PTMs) of Wnt pathway components are essential for the activation of the Wnt/β-catenin pathway. PTMs create a highly dynamic relay system that responds to Wnt stimulation without requiring de novo protein synthesis and offer a platform for non-Wnt pathway components to be involved in the regulation of Wnt signaling, hence providing alternative opportunities for targeting the Wnt pathway. This review highlights the current status of PTM-mediated regulation of the Wnt/β-catenin pathway with a focus on factors involved in Wnt-mediated stabilization of β-catenin. © 2014 Gao et al.; licensee BioMed Central Ltd.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Gao, Cchg52@pitt.eduCHG52
Xiao, Ggux8@pitt.eduGUX8
Hu, Jjih25@pitt.eduJIH25
Centers: Other Centers, Institutes, Offices, or Units > Pittsburgh Cancer Institute
Date: 4 March 2014
Date Type: Publication
Journal or Publication Title: Cell and Bioscience
Volume: 4
Number: 1
DOI or Unique Handle: 10.1186/2045-3701-4-13
Schools and Programs: School of Medicine > Microbiology and Molecular Genetics
School of Medicine > Pharmacology and Chemical Biology
Refereed: Yes
Article Type: Review
Date Deposited: 02 Dec 2016 20:36
Last Modified: 29 Jan 2019 15:55


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item