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Regional pulse wave velocities and their cardiovascular risk factors among healthy middle-aged men: A cross-sectional population-based study

Choo, J and Shin, C and Barinas-Mitchell, E and Masaki, K and Willcox, BJ and Seto, TB and Ueshima, H and Lee, S and Miura, K and Venkitachalam, L and Mackey, RH and Evans, RW and Kuller, LH and Sutton-Tyrrell, K and Sekikawa, A (2014) Regional pulse wave velocities and their cardiovascular risk factors among healthy middle-aged men: A cross-sectional population-based study. BMC Cardiovascular Disorders, 14.

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Abstract

Background: Both carotid-femoral (cf) pulse wave velocity (PWV) and brachial-ankle (ba) PWV employ arterial sites that are not consistent with the path of blood flow. Few previous studies have reported the differential characteristics between cfPWV and baPWV by simultaneously comparing these with measures of pure central (aorta) and peripheral (leg) arterial stiffness, i.e., heart-femoral (hf) PWV and femoral-ankle (fa) PWV in healthy populations. We aimed to identify the degree to which these commonly used measures of cfPWV and baPWV correlate with hfPWV and faPWV, respectively, and to evaluate whether both cfPWV and baPWV are consistent with either hfPWV or faPWV in their associations with cardiovascular (CV) risk factors.Methods: A population-based sample of healthy 784 men aged 40-49 (202 white Americans, 68 African Americans, 202 Japanese-Americans, and 282 Koreans) was examined in this cross-sectional study. Four regional PWVs were simultaneously measured by an automated tonometry/plethysmography system.Results: cfPWV correlated strongly with hfPWV (r = .81, P < .001), but weakly with faPWV (r = .12, P = .001). baPWV correlated moderately with both hfPWV (r = .47, P < .001) and faPWV (r = .62, P < .001). After stepwise regression analyses with adjustments for race, cfPWV shared common significant correlates with both hfPWV and faPWV: systolic blood pressure (BP) and body mass index (BMI). However, BMI was positively associated with hfPWV and cfPWV, and negatively associated with faPWV. baPWV shared common significant correlates with hfPWV: age and systolic BP. baPWV also shared the following correlates with faPWV: systolic BP, triglycerides, and current smoking.Conclusions: Among healthy men aged 40 - 49, cfPWV correlated strongly with central PWV, and baPWV correlated with both central and peripheral PWVs. Of the CV risk factors, systolic BP was uniformly associated with all the regional PWVs. In the associations with factors other than systolic BP, cfPWV was consistent with central PWV, while baPWV was consistent with both central and peripheral PWVs. © 2014 Choo et al.; licensee BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Choo, J
Shin, C
Barinas-Mitchell, Ebarinas@edc.pitt.eduEJB40000-0002-7280-7781
Masaki, K
Willcox, BJ
Seto, TB
Ueshima, H
Lee, S
Miura, K
Venkitachalam, L
Mackey, RHepidrhm@pitt.eduEPIDRHM
Evans, RWEvansR@edc.pitt.eduRWE2
Kuller, LHKullerL@edc.pitt.eduKULLER
Sutton-Tyrrell, K
Sekikawa, Aakira@pitt.eduAKIRA
Date: 13 January 2014
Date Type: Publication
Journal or Publication Title: BMC Cardiovascular Disorders
Volume: 14
DOI or Unique Handle: 10.1186/1471-2261-14-5
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
Date Deposited: 02 Dec 2016 20:21
Last Modified: 28 Oct 2019 12:55
URI: http://d-scholarship.pitt.edu/id/eprint/29619

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