Of ions and temperature: The complicated interplay of temperature, fluids, and electrolytes on myocardial function

Polderman, KH (2013) Of ions and temperature: The complicated interplay of temperature, fluids, and electrolytes on myocardial function. Critical Care, 17 (6). ISSN 1364-8535

Preview	PDF Published Version Available under License : See the attached license file. Download (202kB) | Preview
	Plain Text (licence) Available under License : See the attached license file. Download (1kB)

Abstract

This article discusses the potential of levosimendan to treat calcium-induced myocardial dysfunction associated with deep hypothermia. Moderate hypothermia (30 to 34°C) usually improves myocardial contractility and stabilizes heart rhythm, but deep hypothermia can cause severe myocardial dysfunction, which is mediated by intracellular calcium overload. In experimental studies, levosimendan appears effective in reversing this. Clinical studies are needed to confirm these findings and to determine whether levosimendan could also be used for accidental hypothermia and perhaps to mitigate diastolic dysfunction under moderate hypothermia. © 2013 BioMed Central Ltd.

---

Share

Citation/Export:	Select format... Citation - Text Citation - HTML Endnote BibTex Dublin Core OpenURL MARC (ISO 2709) METS MODS EP3 XML Reference Manager Refer
Social Networking:	Share |

---

Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Polderman, KH khp5@pitt.edu KHP5
Date:	4 December 2013
Date Type:	Publication
Journal or Publication Title:	Critical Care
Volume:	17
Number:	6
DOI or Unique Handle:	10.1186/cc13139
Schools and Programs:	School of Medicine > Critical Care Medicine
Refereed:	Yes
ISSN:	1364-8535
Date Deposited:	02 Dec 2016 18:26
Last Modified:	05 Feb 2019 11:55
URI:	http://d-scholarship.pitt.edu/id/eprint/29638

---

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com

---

Actions (login required)

View Item