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COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups

Sachdev, PS and Lipnicki, DM and Kochan, NA and Crawford, JD and Rockwood, K and Xiao, S and Li, J and Li, X and Brayne, C and Matthews, FE and Stephan, BCM and Lipton, RB and Katz, MJ and Ritchie, K and Carrière, I and Ancelin, ML and Seshadri, S and Au, R and Beiser, AS and Lam, LCW and Wong, CHY and Fung, AWT and Kim, KW and Han, JW and Kim, TH and Petersen, RC and Roberts, RO and Mielke, MM and Ganguli, M and Dodge, HH and Hughes, T and Anstey, KJ and Cherbuin, N and Butterworth, P and Ng, TP and Gao, Q and Reppermund, S and Brodaty, H and Meguro, K and Schupf, N and Manly, J and Stern, Y and Lobo, A and Lopez-Anton, R and Santabárbara, J (2013) COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. BMC Neurology, 13.

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Abstract

Background: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.Methods/Design: Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress.Discussion: The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing. © 2013 Sachdev et al.; licensee BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Sachdev, PS
Lipnicki, DM
Kochan, NA
Crawford, JD
Rockwood, K
Xiao, S
Li, J
Li, X
Brayne, C
Matthews, FE
Stephan, BCM
Lipton, RB
Katz, MJ
Ritchie, K
Carrière, I
Ancelin, ML
Seshadri, S
Au, R
Beiser, AS
Lam, LCW
Wong, CHY
Fung, AWT
Kim, KW
Han, JW
Kim, TH
Petersen, RC
Roberts, RO
Mielke, MM
Ganguli, Mgangulim@pitt.eduGANGULIM
Dodge, HH
Hughes, Tthf9@pitt.eduTHF9
Anstey, KJ
Cherbuin, N
Butterworth, P
Ng, TP
Gao, Q
Reppermund, S
Brodaty, H
Meguro, K
Schupf, N
Manly, J
Stern, Y
Lobo, A
Lopez-Anton, R
Santabárbara, J
Date: 6 November 2013
Date Type: Publication
Journal or Publication Title: BMC Neurology
Volume: 13
DOI or Unique Handle: 10.1186/1471-2377-13-165
Schools and Programs: Graduate School of Public Health > Epidemiology
School of Medicine > Neurology
School of Medicine > Psychiatry
Refereed: Yes
Date Deposited: 02 Dec 2016 16:11
Last Modified: 02 Feb 2019 16:58
URI: http://d-scholarship.pitt.edu/id/eprint/29657

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