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Update of the human and mouse SERPIN gene superfamily

Heit, C and Jackson, BC and McAndrews, M and Wright, MW and Thompson, DC and Silverman, GA and Nebert, DW and Vasiliou, V (2013) Update of the human and mouse SERPIN gene superfamily. Human Genomics, 7 (1). ISSN 1473-9542

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The serpin family comprises a structurally similar, yet functionally diverse, set of proteins. Named originally for their function as serine proteinase inhibitors, many of its members are not inhibitors but rather chaperones, involved in storage, transport, and other roles. Serpins are found in genomes of all kingdoms, with 36 human protein-coding genes and five pseudogenes. The mouse has 60 Serpin functional genes, many of which are orthologous to human SERPIN genes and some of which have expanded into multiple paralogous genes. Serpins are found in tissues throughout the body; whereas most are extracellular, there is a class of intracellular serpins. Serpins appear to have roles in inflammation, immune function, tumorigenesis, blood clotting, dementia, and cancer metastasis. Further characterization of these proteins will likely reveal potential biomarkers and therapeutic targets for disease. © 2013 Heit et al.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Heit, C
Jackson, BC
McAndrews, M
Wright, MW
Thompson, DC
Silverman, GAgas12@pitt.eduGAS12
Nebert, DW
Vasiliou, V
Date: 1 January 2013
Date Type: Publication
Journal or Publication Title: Human Genomics
Volume: 7
Number: 1
DOI or Unique Handle: 10.1186/1479-7364-7-22
Schools and Programs: School of Medicine > Cell Biology
School of Medicine > Pediatrics
Refereed: Yes
ISSN: 1473-9542
Date Deposited: 02 Dec 2016 16:09
Last Modified: 02 Feb 2019 14:55


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