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Myocardial T1 mapping and extracellular volume quantification: A Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement

Moon, JC and Messroghli, DR and Kellman, P and Piechnik, SK and Robson, MD and Ugander, M and Gatehouse, PD and Arai, AE and Friedrich, MG and Neubauer, S and Schulz-Menger, J and Schelbert, EB (2013) Myocardial T1 mapping and extracellular volume quantification: A Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. Journal of Cardiovascular Magnetic Resonance, 15 (1). ISSN 1097-6647

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Abstract

Rapid innovations in cardiovascular magnetic resonance (CMR) now permit the routine acquisition of quantitative measures of myocardial and blood T1 which are key tissue characteristics. These capabilities introduce a new frontier in cardiology, enabling the practitioner/investigator to quantify biologically important myocardial properties that otherwise can be difficult to ascertain clinically. CMR may be able to track biologically important changes in the myocardium by: a) native T1 that reflects myocardial disease involving the myocyte and interstitium without use of gadolinium based contrast agents (GBCA), or b) the extracellular volume fraction (ECV)-a direct GBCA-based measurement of the size of the extracellular space, reflecting interstitial disease. The latter technique attempts to dichotomize the myocardium into its cellular and interstitial components with estimates expressed as volume fractions. This document provides recommendations for clinical and research T1 and ECV measurement, based on published evidence when available and expert consensus when not. We address site preparation, scan type, scan planning and acquisition, quality control, visualisation and analysis, technical development. We also address controversies in the field. While ECV and native T1 mapping appear destined to affect clinical decision making, they lack multi-centre application and face significant challenges, which demand a community-wide approach among stakeholders. At present, ECV and native T1 mapping appear sufficiently robust for many diseases; yet more research is required before a large-scale application for clinical decision-making can be recommended. ©2013 Moon et al.;licensee BioMed Central Ltd.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Moon, JC
Messroghli, DR
Kellman, P
Piechnik, SK
Robson, MD
Ugander, M
Gatehouse, PD
Arai, AE
Friedrich, MG
Neubauer, S
Schulz-Menger, J
Schelbert, EBers77@pitt.eduERS77
Date: 16 October 2013
Date Type: Publication
Journal or Publication Title: Journal of Cardiovascular Magnetic Resonance
Volume: 15
Number: 1
DOI or Unique Handle: 10.1186/1532-429x-15-92
Schools and Programs: School of Medicine > Medicine
Refereed: Yes
ISSN: 1097-6647
Date Deposited: 02 Dec 2016 16:09
Last Modified: 02 Feb 2019 23:55
URI: http://d-scholarship.pitt.edu/id/eprint/29670

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