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Profilin-1 versus profilin-2: Two faces of the same coin?

Ding, Z and Roy, P (2013) Profilin-1 versus profilin-2: Two faces of the same coin? Breast Cancer Research, 15 (3). ISSN 1465-5411

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Abstract

Proteins belonging to the profilin family of actin-binding proteins are considered to be important control elements for actin polymerization and have been linked to a broad spectrum of cellular functions, including cell migration. An intriguing paper recently published in Cancer Cell unveils differential effects of profilin-1 and profilin-2, the two major isoforms of profilin, on actin cytoskeletal regulation, motility, and invasion of breast cancer cells, and further establishes a mechanism underlying profilin-2's suppressive effect on breast cancer cell migration. This viewpoint discusses the implications of these findings in the context of how profilins might regulate breast cancer cell motility. © 2013 BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Ding, Zzhd3@pitt.eduZHD3
Roy, Ppar19@pitt.eduPAR19
Centers: Other Centers, Institutes, or Units > Magee-Women's Research Institute
Other Centers, Institutes, or Units > McGowan Institute for Regenerative Medicine
Date: 27 June 2013
Date Type: Publication
Journal or Publication Title: Breast Cancer Research
Volume: 15
Number: 3
DOI or Unique Handle: 10.1186/bcr3433
Schools and Programs: School of Medicine > Pathology
Swanson School of Engineering > Bioengineering
Refereed: Yes
ISSN: 1465-5411
Date Deposited: 29 Sep 2016 19:59
Last Modified: 25 Jan 2019 23:55
URI: http://d-scholarship.pitt.edu/id/eprint/29711

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