Profilin-1 versus profilin-2: Two faces of the same coin?

Ding, Z and Roy, P (2013) Profilin-1 versus profilin-2: Two faces of the same coin? Breast Cancer Research, 15 (3). ISSN 1465-5411

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Abstract

Proteins belonging to the profilin family of actin-binding proteins are considered to be important control elements for actin polymerization and have been linked to a broad spectrum of cellular functions, including cell migration. An intriguing paper recently published in Cancer Cell unveils differential effects of profilin-1 and profilin-2, the two major isoforms of profilin, on actin cytoskeletal regulation, motility, and invasion of breast cancer cells, and further establishes a mechanism underlying profilin-2's suppressive effect on breast cancer cell migration. This viewpoint discusses the implications of these findings in the context of how profilins might regulate breast cancer cell motility. © 2013 BioMed Central Ltd.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Ding, Z zhd3@pitt.edu ZHD3 Roy, P par19@pitt.edu PAR19
Centers:	Other Centers, Institutes, Offices, or Units > Magee-Women's Research Institute Other Centers, Institutes, Offices, or Units > McGowan Institute for Regenerative Medicine
Date:	27 June 2013
Date Type:	Publication
Journal or Publication Title:	Breast Cancer Research
Volume:	15
Number:	3
DOI or Unique Handle:	10.1186/bcr3433
Schools and Programs:	School of Medicine > Pathology Swanson School of Engineering > Bioengineering
Refereed:	Yes
ISSN:	1465-5411
Date Deposited:	29 Sep 2016 19:59
Last Modified:	25 Jan 2019 23:55
URI:	http://d-scholarship.pitt.edu/id/eprint/29711

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