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Cytokine-induced killer cells promote antitumor immunity

Jiang, J and Wu, C and Lu, B (2013) Cytokine-induced killer cells promote antitumor immunity. Journal of Translational Medicine, 11 (1).

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The number of immune cells, especially dendritic cells and cytotoxic tumor infiltrating lymphocytes (TIL), particularly Th1 cells, CD8 T cells, and NK cells is associated with increased survival of cancer patients. Such antitumor cellular immune responses can be greatly enhanced by adoptive transfer of activated type 1 lymphocytes. Recently, adoptive cell therapy based on infusion of ex vivo expanded TILs has achieved substantial clinical success. Cytokine-induced killer (CIK) cells are a heterogeneous population of effector CD8 T cells with diverse TCR specificities, possessing non-MHC-restricted cytolytic activities against tumor cells. Preclinical studies of CIK cells in murine tumor models demonstrate significant antitumor effects against a number of hematopoietic and solid tumors. Clinical studies have confirmed benefit and safety of CIK cell-based therapy for patients with comparable malignancies. Enhancing the potency and specificity of CIK therapy via immunological and genetic engineering approaches and identifying robust biomarkers of response will significantly improve this therapy. © 2013 Jiang et al.; licensee BioMed Central Ltd.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Jiang, J
Wu, C
Lu, Bbinfeng@pitt.eduBINFENG
Date: 28 March 2013
Date Type: Publication
Journal or Publication Title: Journal of Translational Medicine
Volume: 11
Number: 1
DOI or Unique Handle: 10.1186/1479-5876-11-83
Schools and Programs: School of Medicine > Immunology
Refereed: Yes
Article Type: Review
Date Deposited: 04 Oct 2016 18:07
Last Modified: 02 Feb 2019 16:58


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