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Effects of smoking on the genetic risk of obesity: The population architecture using genomics and epidemiology study

Fesinmeyer, MD and North, KE and Lim, U and Bůžková, P and Crawford, DC and Haessler, J and Gross, MD and Fowke, JH and Goodloe, R and Love, SA and Graff, M and Carlson, CS and Kuller, LH and Matise, TC and Hong, CP and Henderson, BE and Allen, M and Rohde, RR and Mayo, P and Schnetz-Boutaud, N and Monroe, KR and Ritchie, MD and Prentice, RL and Kolonel, LN and Manson, JAE and Pankow, J and Hindorff, LA and Franceschini, N and Wilkens, LR and Haiman, CA and Le Marchand, L and Peters, U (2013) Effects of smoking on the genetic risk of obesity: The population architecture using genomics and epidemiology study. BMC Medical Genetics, 14 (1).

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Abstract

Background: Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored.Methods: As part of the 'Population Architecture using Genomics and Epidemiology (PAGE)' Consortium, we investigated interaction between genetic risk factors associated with BMI and smoking for 10 single nucleotide polymorphisms (SNPs) previously identified in genome-wide association studies. We included 6 studies with a total of 56,466 subjects (16,750 African Americans (AA) and 39,716 European Americans (EA)). We assessed effect modification by testing an interaction term for each SNP and smoking (current vs. former/never) in the linear regression and by stratified analyses.Results: We did not observe strong evidence for interactions and only observed two interactions with p-values <0.1: for rs6548238/TMEM18, the risk allele (C) was associated with BMI only among AA females who were former/never smokers (β = 0.018, p = 0.002), vs. current smokers (β = 0.001, p = 0.95, pinteraction = 0.10). For rs9939609/FTO, the A allele was more strongly associated with BMI among current smoker EA females (β = 0.017, p = 3.5x10-5), vs. former/never smokers (β = 0.006, p = 0.05, pinteraction = 0.08).Conclusions: These analyses provide limited evidence that smoking status may modify genetic effects of previously identified genetic risk factors for BMI. Larger studies are needed to follow up our results.Clinical Trial Registration: NCT00000611. © 2013 Fesinmeyer et al.; licensee BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Fesinmeyer, MD
North, KE
Lim, U
Bůžková, P
Crawford, DC
Haessler, J
Gross, MD
Fowke, JH
Goodloe, R
Love, SA
Graff, M
Carlson, CS
Kuller, LHKullerL@edc.pitt.eduKULLER
Matise, TC
Hong, CP
Henderson, BE
Allen, M
Rohde, RR
Mayo, P
Schnetz-Boutaud, N
Monroe, KR
Ritchie, MD
Prentice, RL
Kolonel, LN
Manson, JAE
Pankow, J
Hindorff, LA
Franceschini, N
Wilkens, LR
Haiman, CA
Le Marchand, L
Peters, U
Date: 11 January 2013
Date Type: Publication
Journal or Publication Title: BMC Medical Genetics
Volume: 14
Number: 1
DOI or Unique Handle: 10.1186/1471-2350-14-6
Schools and Programs: School of Medicine > Medicine
Refereed: Yes
Date Deposited: 06 Oct 2016 19:40
Last Modified: 19 Jan 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/29778

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