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No strings attached: New insights into epithelial morphogenesis

UNSPECIFIED (2012) No strings attached: New insights into epithelial morphogenesis. BMC Biology, 10.

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Abstract

The dramatic ingression of tissue sheets that accompanies many morphogenetic processes, most notably gastrulation, has been largely attributed to contractile circum-apical actomyosin 'purse-strings' in the infolding cells. Recent studies, however, including one in BMC Biology, expose mechanisms that rely less on actomyosin contractility of purse-string bundles and more on dynamics in the global cortical actomyosin network of the cells. These studies illustrate how punctuated actomyosin contractions and flow of these networks can remodel both epithelial and planarly organized mesenchymal sheets. © 2012 Davidson; licensee BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Date: 20 December 2012
Date Type: Publication
Journal or Publication Title: BMC Biology
Volume: 10
DOI or Unique Handle: 10.1186/1741-7007-10-105
Schools and Programs: Swanson School of Engineering > Bioengineering
Refereed: Yes
Date Deposited: 02 Dec 2016 14:56
Last Modified: 05 Jan 2019 14:57
URI: http://d-scholarship.pitt.edu/id/eprint/29786

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