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Who's driving anyway? Herculean efforts to identify the drivers of breast cancer

UNSPECIFIED (2012) Who's driving anyway? Herculean efforts to identify the drivers of breast cancer. Breast Cancer Research, 14 (5). ISSN 1465-5411

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Abstract

The continuing advancement of sequencing technologies has made the systematic identification of all driving somatic events in cancer a possibility. In the June 2012 issue of Nature, five papers show some significant headway in this endeavor, each a herculean effort of genome sequencing, and transcriptome and copy number analysis resulting in data on thousands of breast cancers. Integrating these massive datasets, the authors were able to further subdivide breast cancer and identify a number of novel driver genes. While the studies represent a leap forward in describing the genomics of breast cancer, and clearly highlight the tremendous diversity between tumors, the studies only scrape the surface of molecular changes in breast tumors, with more granularity to come from the study of epigenomics, single cell sequencing, and so on. The immediate importance of the data to clinical care is currently unknown, and will depend upon detailed identification and functional analysis of driver mutations. © 2012 BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Centers: Other Centers, Institutes, or Units > Magee-Women's Research Institute
Other Centers, Institutes, or Units > Pittsburgh Cancer Institute
Date: 31 October 2012
Date Type: Publication
Journal or Publication Title: Breast Cancer Research
Volume: 14
Number: 5
DOI or Unique Handle: 10.1186/bcr3325
Schools and Programs: School of Medicine > Pharmacology and Chemical Biology
Refereed: Yes
ISSN: 1465-5411
Date Deposited: 30 Nov 2016 17:28
Last Modified: 07 Jan 2019 22:55
URI: http://d-scholarship.pitt.edu/id/eprint/29806

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