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NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination?

Xiao, G (2012) NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination? Retrovirology, 9.

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Abstract

Activation of the NF-κB transcription factors by the viral protein Tax plays a vital role in the pathogenesis of diseases associated with human T-cell lymphotropic virus type I (HTLV-I). The Tax oncoprotein undergoes constitutive K63-linked ubiquitination and sumoylation; however, the roles and molecular mechanisms of these post-translational modifications in Tax-mediated NF-κB activation are being debated. Here, we discuss our current understanding of Tax activation of NF-κB, with a focus on the controversies and the challenges that we are facing. © 2012 Xiao; licensee BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Xiao, Ggux8@pitt.eduGUX8
Centers: Other Centers, Institutes, or Units > Pittsburgh Cancer Institute
Date: 25 September 2012
Date Type: Publication
Journal or Publication Title: Retrovirology
Volume: 9
DOI or Unique Handle: 10.1186/1742-4690-9-78
Schools and Programs: School of Medicine > Microbiology and Molecular Genetics
Refereed: Yes
Date Deposited: 11 Oct 2016 18:31
Last Modified: 24 Jan 2019 00:55
URI: http://d-scholarship.pitt.edu/id/eprint/29827

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